2795-63-3

Basic information

• Product Name: 2-(4-FLUOROPHENOXY)BENZOIC ACID
• Synonyms: 2-(4-FLUOROPHENOXY)BENZOIC ACID
• CAS NO: 2795-63-3
• Molecular Formula: C₁₃H₉FO₃
• Molecular Weight: 232.21
• Mol File: 2795-63-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-FLUOROPHENOXY)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FLUOROPHENOXY)BENZOIC ACID(2795-63-3)
• EPA Substance Registry System: 2-(4-FLUOROPHENOXY)BENZOIC ACID(2795-63-3)

Safety Data

• Hazardous Substances Data: 2795-63-3(Hazardous Substances Data)

Usage

Molar mass

232.21 g/mol

Physical form

White to off-white crystalline powder

Solubility

Insoluble in water

Usage

Commonly used as an intermediate in the synthesis of various drugs in the pharmaceutical industry

Potential uses

Studied for its potential as an antifungal and anti-inflammatory agent

Unique property

Presence of a fluorine atom in its structure giving it certain chemical properties useful for various applications

Research status

Further research needed to fully explore its potential uses and properties.

Upstream product

• 371-41-5 4-Fluorophenol 
• 88-67-5 2-Iodobenzoic acid 
• 1135619-95-2 2-(4-fluoro-phenoxy)-benzoic acid ethyl ester 
• 118-91-2 ortho-chlorobenzoic acid 
• 394-47-8 2-fluorobenzonitrile 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 448-24-8 2-(4-fluoro-phenoxy)-benzoic acid methyl ester 

Downstream Products

• 2839-49-8 2-fluoro-9H-xanthen-9-one 
• 70764-39-5 [2-(4-fluorophenoxy)phenyl]methanol 
• 859149-01-2 2-(4-fluorophenoxy)-O,N-dimethylbenzamide 
• 391-46-8 2-fluorodibenzo[b,d]furan 
• 330-84-7 4-fluorophenoxybenzene 

Relevant articles and documents

Electrochemical Reductive Smiles Rearrangement for C-N Bond Formation

A conceptually new and synthetically valuable radical Smiles rearrangement reaction is reported under undivided electrolytic conditions. This protocol employs an entirely new strategy for the electrochemical radical Smiles rearrangement. Remarkably, an amidyl radical generated from the cleavage of the N-O bond under reductive electrolytic conditions plays a crucial role in this transformation. Various hydroxylamine derivatives bearing different substituents are suitable in this electrochemical transformation, furnishing the corresponding amides in up to 86% yield.

Efficient Aryl Migration from an Aryl Ether to a Carboxylic Acid Group To Form an Ester by Visible-Light Photoredox Catalysis

We have developed a highly efficient aryl migration from an aryl ether to a carboxylic acid group through retro-Smiles rearrangement by visible-light photoredox catalysis at ambient temperature. Transition metals and a stoichiometric oxidant and base are avoided in the transformation. Inspired by the high efficiency of this transformation and the fundamental importance of C?O bond cleavage, we developed a novel approach to the C?O cleavage of a biaryl ether to form two phenolic compounds, as demonstrated by a one-pot, two-step gram-scale reaction under mild conditions. The aryl migration exhibits broad scope and can be applied to the synthesis of pharmaceutical compounds, such as guacetisal. Primary mechanistic studies indicate that the catalytic cycle occurs by a reductive quenching pathway.

Highly efficient and regiospecific photocyclization of 2,2′-diacyl bixanthenylidenes

In contrast to the reversible photochemistry of the 2,2′-substituted bixanthenylidenes (1a-f), the photocyclization of 2,2′-diacyl bixanthenylidenes (1g-j) reveals an irreversible process where the initial cyclic intermediate C(E) can undergo a rapid [1,1