2799-75-9

Basic information

• Product Name: 5,6-dihydro-4H-1,3-thiazin-2-amine hydrobromide (1:1)
• Synonyms: 5,6-dihydro-4H-1,3-thiazin-2-amine hydrobromide
• CAS NO: 2799-75-9
• Molecular Formula: BrH*C₄H₈N₂S
• Molecular Weight: 197.0967
• EINECS: 826-137-3
• Mol File: 2799-75-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 235.3°C at 760 mmHg
• Flash Point: 96.1°C
• Vapor Pressure: 0.0505mmHg at 25°C
• CAS DataBase Reference: 5,6-dihydro-4H-1,3-thiazin-2-amine hydrobromide (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-dihydro-4H-1,3-thiazin-2-amine hydrobromide (1:1)(2799-75-9)
• EPA Substance Registry System: 5,6-dihydro-4H-1,3-thiazin-2-amine hydrobromide (1:1)(2799-75-9)

Safety Data

• Hazardous Substances Data: 2799-75-9(Hazardous Substances Data)

Upstream product

• 7072-40-4 S-(3-aminopropyl)isothiourea dihydrobromide 
• 86768-93-6 2-(3-Bromo-propyl)-isothiourea; hydrobromide 
• 17356-08-0 thiourea 

Downstream Products

• 2799-77-1 N-acetyl-sulfanilic acid-(5,6-dihydro-4H-[1,3]thiazin-2-ylamide) 
• 67410-92-8 N-(5,6-dihydro-4H-[1,3]thiazin-2-yl)-4-fluoro-benzamide 
• 67410-93-9 3-(4-fluoro-benzoyl)-2-(4-fluoro-benzoylimino)-[1,3]thiazinane 
• 2799-76-0 4-acetylamino-N-[3-(4-acetylamino-benzenesulfonyl)-[1,3]thiazinan-2-ylidene]-benzenesulfonamide 

Relevant articles and documents

Protective effects of 2-amino-5,6-dihydro-4h-1,3-thiazine and its derivative against radiation-induced hematopoietic and intestinal injury in mice

Ionizing radiation (IR) acts as an external stimulating factor, when it acts on the body, it will activate NF-κB and cause the up-regulation of inducible nitric oxide synthase (iNOS) and induce a large amount of nitric oxide (NO) production. NO and other reactive nitrogen and oxygen species (RNS and ROS) can cause damage to biological molecules and affect their physiological functions. Our study investigated the protective role of 2-amino-5,6-dihydro-4H-1,3-thiazine hydrobromide (2-ADT) and 2-acetylamino-5,6-dihydro-4H-1,3-thiazine hydrobromide (2-AADT), two nitric oxide synthase inhibitors, against radiation-induced hematopoietic and intestinal injury in mice. Pretreatment with 2-ADT and 2-AADT improved the survival of mice exposed to a lethal dose of radiation, especially, the survival rate of the 2-ADT 20 mg/kg group was significantly higher than that of the vehicle group (p 0.001). Our findings indicated that the radioprotective actions of 2-ADT and 2-AADT are achieved via accelerating hematopoietic system recovery, decreasing oxidative and nitrosative stress by enhancing the antioxidant defense system and reducing NO as well as peroxynitrite (ONOO?) content, and mitigating the radiation-induced DNA damage evaluated by comet assay. These results suggest that 2-ADT and 2-AADT may have great application potential in ameliorating the damages of radiotherapy.

S-DERIVATIVES OF THIOUREA. XX. REACTION OF THIOUREA WITH TERMINAL DIBROMOALKANES

The kinetics of the reaction of thiourea with terminal dibromoalkanes Br(CH2)nBr, where n= 1-5, were investigated by radiochromatography.It was established that the reaction of thiourea with 1,4-dibromobutane and 1,5-dibromopentane leads to the formation of only products from substitution of one or two bromine atoms by thiourea.In the case of 1,2-dibromoethane and 1,3-dibromopropane 2-amino-2-thiazoline and 2-amino-5,6-dihydro-4H-1,3-thiazine were found in addition to the analogous substitution products.The rate constants of the individual stages of the processes were determined.A series of S-bromoalkylisothioureas Br(CH2)nSC+.(NH2)2Br-, where n= 2-5, were synthesized.It was shown that the rate of their reaction with thiourea is higher than for terminal dibromoalkanes and (for n= 3-5) alkyl halides Br(CH2)nH.It was found that the reactivity varies irregularly with increases in the length of the polymethylene chain for bromoalkylisothioureas, and this evidently results from the superimposition of several effects from the substituent.