28008-55-1 Usage
Description
DAUNOMYCINOL, also known as Daunorubicinol, is an aminoglycoside antibiotic derived from the metabolite of Daunorubicin. It is characterized by its unique chemical structure, featuring a 3-amino-2,3,6-trideoxy-alpha-L-lyxo/stereo-hexopyranosyl residue attached at position 1 via a glycosidic linkage. DAUNOMYCINOL possesses potent biological activities and has been extensively studied for its therapeutic potential.
Uses
Used in Pharmaceutical Industry:
DAUNOMYCINOL is used as an anticancer agent for its potent activity against various types of cancer. It is particularly effective against solid malignancies such as liver, breast, lung, pancreatic, colorectal, and ovarian cancers. DAUNOMYCINOL modulates several oncological signaling pathways, including JAK/STAT, RAS/RAF/mTOR, TGF-β1/TGF-β1R, VEGF/VEGFR, and CXCL12/CXCR4 axes, exerting inhibitory effects on tumor growth and progression.
Additionally, DAUNOMYCINOL demonstrates synergistic anticancer effects when combined with conventional chemotherapeutic drugs, enhancing chemo-sensitivity and efficacy in resistant cases.
Used in Drug Delivery Systems:
To overcome the limitations of DAUNOMYCINOL, such as poor solubility and bioavailability, novel drug delivery systems have been developed. These systems employ various organic and metallic nanoparticles as carriers for DAUNOMYCINOL delivery, aiming to improve its pharmacokinetics, bioavailability, and therapeutic outcomes. This approach has the potential to enhance the efficacy of DAUNOMYCINOL in cancer treatment and reduce side effects associated with conventional chemotherapy.
Check Digit Verification of cas no
The CAS Registry Mumber 28008-55-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,0,0 and 8 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 28008-55:
(7*2)+(6*8)+(5*0)+(4*0)+(3*8)+(2*5)+(1*5)=101
101 % 10 = 1
So 28008-55-1 is a valid CAS Registry Number.
InChI:InChI=1/C27H31NO10/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33/h4-6,10-11,14,16-17,22,29-30,32,34-35H,7-9,28H2,1-3H3/t10-,11?,14-,16-,17-,22+,27-/m0/s1
