2801-07-2

Basic information

• Product Name: Cyclohexyldithiocarbamic acid sodium salt
• Synonyms: Cyclohexyldithiocarbamic acid sodium salt;sodium cyclohexylcarbamodithioate
• CAS NO: 2801-07-2
• Molecular Formula: C₇H₁₂NS₂*Na
• Molecular Weight: 175.3148
• Mol File: 2801-07-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 245.9°Cat760mmHg
• Flash Point: 102.5°C
• Appearance: /
• Density: 1.13g/cm³
• Vapor Pressure: 0.028mmHg at 25°C
• Refractive Index: 1.577
• CAS DataBase Reference: Cyclohexyldithiocarbamic acid sodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexyldithiocarbamic acid sodium salt(2801-07-2)
• EPA Substance Registry System: Cyclohexyldithiocarbamic acid sodium salt(2801-07-2)

Safety Data

• Hazardous Substances Data: 2801-07-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H13NS2/c9-7(10)8-6-4-2-1-3-5-6/h6H,1-5H2,(H2,8,9,10)

Upstream product

• 75-15-0 carbon disulfide 
• 108-91-8 cyclohexylamine 

Downstream Products

• 30736-24-4 3-cyclohexylamino-4-phenyl-cyclobut-3-ene-1,2-dione 
• 72807-82-0 Cyclohexyl-dithiocarbamic acid 3,4-dioxo-2-phenyl-cyclobut-1-enyl ester 
• 118444-36-3 In(C₆H₁₁NHCS₂)3 
• 52201-70-4 C₅H₅Ni(P(C₄H₉-n)3)SC(S)NHC₆H₁₁-cyclo 
• 13037-17-7 Cyclohexyldithiocarbamidsaeure-methylester 

Relevant articles and documents

4-Aryl-2-Imino-1,3-Dithiolanes from the Room Temperature Coupling of Sodium Dithiocarbamates with Sulfonium Salts

A series of 4-aryl-2-imino-1,3-dithiolanes was synthesized by means of a straightforward strategy starting from readily available precursors: reactions of dithiocarbamates and arylsulfonium salts, at room temperature in water/CH2Cl2 as biphasic medium, afforded the five-membered cyclic products in good yields. The reaction mechanism was investigated by DFT calculations.

Design, Synthesis, Molecular Docking, and Cholinesterase Inhibitory Potential of Phthalimide-Dithiocarbamate Hybrids as New Agents for Treatment of Alzheimer's Disease

A novel series of phthalimide-dithiocarbamate hybrids was synthesized and evaluated for in vitro inhibitory potentials against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The anti-cholinesterase results indicated that among the synthesized compounds, the compounds 7g and 7h showed the most potent anti-AChE and anti-BuChE activities, respectively. Molecular docking and dynamic studies of the compounds 7g and 7h, respectively, in the active site of AChE and BuChE revealed that these compounds as well interacted with studied cholinesterases. These compounds also possessed drug-like properties and were able to cross the BBB.

Synthesis, characterization and biodistribution of a (99m)Tc nitrido complex as a potential brain perfusion imaging agent

The bis(N-cyclohexyl-dithiocarbamato) nitrido technetium-99m complex [(99m)TcN(CHDTC)2] (CHDTC:N-cyclohexyl dithiocarbamato) has been synthesized through a ligand-exchange reaction. The two-step procedure involved the initial reaction of (99m)TcO4- with succinic dihydrazide (SDH) in the presence of stannous chloride as reducing agent and propylenediamine tetraacetic acid (PDTA) as complexant, followed by the addition of sodium N-cyclohexyl dithiocarbamate dihydrate. The radiochemical purity of the complex was over 90% by thin layer chromatography. It was stable over 6 h at room temperature. Its partition coefficient indicated that it was a good lipophilic complex. Biodistribution in mice demonstrated that the complex accumulated in brain with high uptake and good retention. The brain uptake (ID%/g) was 2.91, 5.88 and 5.91 at 5, 30 and 60 min post-injection respectively. The ratio of brain/blood in mice was high, 2.10 at 1 hr post-injection. The results for the complex suggested that it could be a potential brain perfusion imaging agent.