280108-15-8

Basic information

• Product Name: 4-Thiazolidinecarboxylic acid, 2-(4-cyanophenyl)-, (4R)-
• CAS NO: 280108-15-8
• Molecular Formula: C11H10N2O2S
• Molecular Weight: 234.279
• Mol File: 280108-15-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-Thiazolidinecarboxylic acid, 2-(4-cyanophenyl)-, (4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Thiazolidinecarboxylic acid, 2-(4-cyanophenyl)-, (4R)-(280108-15-8)
• EPA Substance Registry System: 4-Thiazolidinecarboxylic acid, 2-(4-cyanophenyl)-, (4R)-(280108-15-8)

Safety Data

• Hazardous Substances Data: 280108-15-8(Hazardous Substances Data)

Upstream product

• 52-89-1 l-cysteine hydrochloride 
• 105-07-7 4-cyanobenzaldehyde 

Downstream Products

• 1297309-35-3 3-phenylacetyl-(2RS,4R)-2-(4-cyano-phenyl)-thiazolidine-4-carboxylic acid 
• 1297309-28-4 3-(2-chloro-acetyl)-(2RS,4R)-2-(4-cyano-phenyl)-thiazolidine-4-carboxylic acid 
• 1029799-99-2 (R)-2-(4-cyano-phenyl)-thiazolidine-3,4-dicarboxylic acid 3-benzyl ester 
• 110078-86-9 (2R,4R)-3-Acetyl-2-(4-cyano-phenyl)-thiazolidine-4-carboxylic acid 

Relevant articles and documents

3-Propionyl-thiazolidine-4-carboxylic acid ethyl esters: A family of antiproliferative thiazolidines

Cancer results from unregulated cell growth. Reactivating the process of the programmed cell death, i.e. apoptosis, is a classical anticancer therapeutic strategy. The apoptosis-inducing property of the (2RS,4R)-2-phenyl-3-propionyl-thiazolidine-4-carboxylic acid ethyl ester (ALC 67) molecule has recently been discovered. We analyzed in this study the impact of the phenyl moiety of this molecule on its biological activity by synthesizing and evaluating analogues where this substituent was replaced by a series of aromatic and aliphatic groups. The results demonstrated that the molecule's antiproliferative property resisted such modifications. Thus, in addition to developing a family of thiazolidine compounds with promising anticancer properties; our investigation revealed that the second position of the thiazolidine ring can be used either to tune the physicochemical properties of ALC67 or to introduce a fluorescent tag to the structure in order to track it in cells and determine its exact molecular mechanism of action.

AMIDO ANTI-VIRAL COMPOUNDS

Disclosed are compounds, stereoisomers, tautomers, pharmaceutically acceptable salts, or prodrugs thereof of having Formula (I), their preparation, use, and compositions thereof for treating an infection mediated at least in part by a virus in the Flaviviridae family of viruses, wherein A, R3, X, V, W, T, Z, R, Y1, and p are as defined herein.