28020-36-2

Basic information

• Product Name: N2-methylpyridine-2,5-diamine
• Synonyms: 2-Methylamino-5-pyridinamine;N2-Methyl-2,5-PyridinediaMine;2,5-PyridinediaMine, N2-Methyl-;2-N-METHYLPYRIDINE-2,5-DIAMine
• CAS NO: 28020-36-2
• Molecular Formula: C₆H₉N₃
• Molecular Weight: 123.16
• EINECS: 248-781-9
• Mol File: 28020-36-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 306.4°Cat760mmHg
• Flash Point: 139.1°C
• Appearance: /
• Density: 1.179g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.652
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 7.56±0.10(Predicted)
• CAS DataBase Reference: N2-methylpyridine-2,5-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N2-methylpyridine-2,5-diamine(28020-36-2)
• EPA Substance Registry System: N2-methylpyridine-2,5-diamine(28020-36-2)

Safety Data

• Hazardous Substances Data: 28020-36-2(Hazardous Substances Data)

Usage

General Description

N2-methylpyridine-2,5-diamine, also known as 2,5-diaminopyridine and 2-methyl-pyridine-2,5-diamine, is a chemical compound with the molecular formula C7H10N2. It is a white to slightly yellow crystalline solid that is soluble in water and organic solvents. N2-methylpyridine-2,5-diamine is commonly used in the synthesis of pharmaceuticals, dyes, and other organic compounds. It is also used as a hair dye intermediate and in the production of hair color products. N2-methylpyridine-2,5-diamine is considered to be a moderately hazardous chemical and proper safety precautions should be taken when handling and storing it.

InChI:InChI=1/C6H9N3/c1-8-6-3-2-5(7)4-9-6/h2-4H,7H2,1H3,(H,8,9)

Upstream product

• 4093-89-4 N-methyl-5-nitropyridin-2-amine 
• 4548-45-2 2-chloro-5-nitropyridine 

Downstream Products

• 1003938-50-8 N-[6-(methylamino)pyridin-3-yl]-5-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxamide 
• 1034710-92-3 1-(3-Fluorobenzyl)-5-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid (6-(methylamino)pyridin-3-yl)amide 

Relevant articles and documents

Discovery of novel dual inhibitors of VEGFR and PI3K kinases containing 2-ureidothiazole scaffold

A series of compounds possessing 2-(3-phenyl)ureidothiazol-4-formamide derivatives with a 2-ureidothiazole scaffold were designed and synthesized. Some compounds demonstrated inhibition of cell proliferation against both MDA-MB-231 and HepG2 cell lines using Sorafenib as the positive control. Compounds 6i showed a good to moderate inhibition on VEGFR-2 and PI3Kα which was proved by further molecular docking study. This study suggests that compound 6i is a potential dual inhibitor of VEGFR-2 and PI3Kα and is applicable for further investigation.

SUBSTITUTED TRIAZOLE DERIVATIVES AS OXYTOCIN ANTAGONISTS

The present invention relates to a class of substituted triazoles of formula (I) with activity as oxytoci antagonists, uses thereof, processes for the preparation thereof and compositions containing sai inhibitors. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction particularly premature ejaculation (P.E.).

Novel potassium channel openers: Synthesis and pharmacological evaluation of new N-(substituted-3-pyridyl)-N'-alkylthioureas and related compounds

This report describes the synthesis and pharmacological evaluation of a series of novel potassium channel openers related to the pinacidil-type compounds. Thioureas, cyanoguanidines, and pyridine N-oxides were systematically evaluated for their effects on both the inhibition of spontaneous mechanical activity in rat portal vein (in vitro) and their antihypertensive activity (in vivo), and the structure-activity relationship for this series of compounds was discussed. Good correlation between in vitro and iv antihypertensive activity was observed for these compounds. Among them, cyanoguanidines bearing a conformationally rigid unit such as a norbornyl group generally possessed potent activity in both in vitro and in vivo studies. Especially, N-(6-amino-3-pyridyl)-N'-cyano-N''-(1-methyl-2- norbornyl)guanidine (23d) was identified as a more potent potassium channel opener in vitro (EC100 = 3 x 10-8 M) than pinacidil (EC100 = 10-7 M).