280570-45-8 Usage
Description
VUF 5574 is an adenosine A3 receptor antagonist with high selectivity for the adenosine A3 receptor over A1 and A2A receptors. It has been shown to decrease phosphorylation of ERK1/2 induced by adenosine in isolated porcine coronary artery smooth muscle cells and increase oxygen-glucose deprivation-induced reductions in the amplitude of field excitatory postsynaptic potentials (EPSPs) in a rat hippocampal slice model of ischemia.
Uses
Used in Pharmaceutical Industry:
VUF 5574 is used as an adenosine A3 receptor antagonist for its potential therapeutic applications in various conditions, such as ischemia and heart rate regulation. Its high selectivity for the adenosine A3 receptor makes it a promising candidate for the development of targeted treatments.
Used in Cardiovascular Research:
VUF 5574 is used as a research tool for studying the role of adenosine A3 receptors in cardiovascular function. Its ability to reduce sodium nitroprusside-induced heart rate increases in rats makes it a valuable compound for investigating the mechanisms underlying heart rate regulation and potential therapeutic interventions.
Used in Neurological Research:
VUF 5574 is used as a research tool in the study of ischemia and its effects on the nervous system. By increasing oxygen-glucose deprivation-induced reductions in the amplitude of field excitatory postsynaptic potentials (EPSPs) in a rat hippocampal slice model of ischemia, VUF 5574 helps researchers understand the role of adenosine A3 receptors in neuroprotection and the development of potential treatments for ischemic conditions.
Biological Activity
Potent, selective, competitive antagonist for the human adenosine A 3 receptor (K i = 4 nM). Displays ≥ 2500-fold selectivity over A 1 and A 2A receptors.
Check Digit Verification of cas no
The CAS Registry Mumber 280570-45-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,0,5,7 and 0 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 280570-45:
(8*2)+(7*8)+(6*0)+(5*5)+(4*7)+(3*0)+(2*4)+(1*5)=138
138 % 10 = 8
So 280570-45-8 is a valid CAS Registry Number.
InChI:InChI=1/C21H17N5O2/c1-28-18-11-5-4-10-17(18)24-21(27)26-20-15-8-2-3-9-16(15)23-19(25-20)14-7-6-12-22-13-14/h2-13H,1H3,(H2,23,24,25,26,27)
280570-45-8Relevant articles and documents
Expeditious Synthesis of 2-Phenylquinazolin-4-amines via a Fe/Cu Relay-Catalyzed Domino Strategy
Jia, Feng-Cheng,Zhou, Zhi-Wen,Xu, Cheng,Cai, Qun,Li, Deng-Kui,Wu, An-Xin
, p. 4236 - 4239 (2015/09/15)
A highly efficient Fe/Cu relay-catalyzed domino protocol has been developed for the synthesis of 2-phenylquinazolin-4-amines from commercially available ortho-halogenated benzonitriles, aldehydes, and sodium azide. This elegant domino process involved con
