281191-03-5

Basic information

• Product Name: (2S,2'R,1''S,2''R,1''''R)1''-(3'''-{1''''-[(tert-butoxy)carbonyl]-2''''-p-methoxyphenylethylcarbamoyl}allyl)-2''-methyl-4''-phenylbut-3''-enyl 2-[(3'-{[(tert-butoxy)carbonyl]amino}-2'-methylpropionyl)oxy]-4-methylpentanoate
• Synonyms: (2S,2'R,1''S,2''R,1''''R)1''-(3'''-{1''''-[(tert-butoxy)carbonyl]-2''''-p-methoxyphenylethylcarbamoyl}allyl)-2''-methyl-4''-phenylbut-3''-enyl 2-[(3'-{[(tert-butoxy)carbonyl]amino}-2'-methylpropionyl)oxy]-4-methylpentanoate
• CAS NO: 281191-03-5
• Molecular Weight: 778.984
• Mol File: 281191-03-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2S,2'R,1''S,2''R,1''''R)1''-(3'''-{1''''-[(tert-butoxy)carbonyl]-2''''-p-methoxyphenylethylcarbamoyl}allyl)-2''-methyl-4''-phenylbut-3''-enyl 2-[(3'-{[(tert-butoxy)carbonyl]amino}-2'-methylpropionyl)oxy]-4-methylpentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,2'R,1''S,2''R,1''''R)1''-(3'''-{1''''-[(tert-butoxy)carbonyl]-2''''-p-methoxyphenylethylcarbamoyl}allyl)-2''-methyl-4''-phenylbut-3''-enyl 2-[(3'-{[(tert-butoxy)carbonyl]amino}-2'-methylpropionyl)oxy]-4-methylpentanoate(281191-03-5)
• EPA Substance Registry System: (2S,2'R,1''S,2''R,1''''R)1''-(3'''-{1''''-[(tert-butoxy)carbonyl]-2''''-p-methoxyphenylethylcarbamoyl}allyl)-2''-methyl-4''-phenylbut-3''-enyl 2-[(3'-{[(tert-butoxy)carbonyl]amino}-2'-methylpropionyl)oxy]-4-methylpentanoate(281191-03-5)

Safety Data

• Hazardous Substances Data: 281191-03-5(Hazardous Substances Data)

Upstream product

• 162465-19-2 (2S,2'R)-2-<<3'<(tert-butoxycarbonyl)amino>-2'-methylpropanoyl>oxy>-4-methylpentanoic acid 
• 281191-02-4 (2R,2'E,5'S,6'R,7'E)-tert-butyl 2-[(5'-hydroxy-6'-methyl-8'-phenylocta-2',7'-dienoyl)amino]-3-(4-methoxyphenyl)propionate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 281190-97-4 (2R,3E,1'S,1''R,2''S)-1''-[(p-tolylsulfonyl)amino]indan-2''-yl 2-[3'-(benzyloxy)-1'-hydroxypropyl]-4-phenylbut-3-enoate 
• 281191-01-3 (2R,2'E,5'S,6'R,7'E)-tert-butyl 3-(4-methoxyphenyl)-2-({6'-methyl-8'-phenyl-5'-[(triisopropylsilanyl)oxy]octa-2',7'-dienoyl}amino)propionate 
• 281190-96-3 (3E,1'R,2'S)-1'-[(p-tolylsulfonyl)amino]indan-2-yl 4-phenylbut-3-enoate 
• 281190-99-6 (1S,2R,3E)-({1-[2'-(benzyloxy)ethyl]-2-methyl-4-phenylbut-3-enyl}oxy)triisopropylsilane 
• 281191-00-2 (2E,5S,6R,7E)-ethyl 6-methyl-8-phenyl-5-[(triisopropylsilanyl)oxy]octa-2,7-dienoate 
• 281190-94-1 (2E,5S,6R,7E)-6-methyl-8-phenyl-5-[(triisopropylsilanyl)oxy]octa-2,7-dienoic acid 
• 728944-91-0 (R)-tert-butyl 2-{[(benzyloxy)carbonyl]amino}-3-(4-methoxyphenyl)propionate 
• 281191-04-6 (3S,4R,5E)-4-methyl-6-phenyl-3-[(triisopropylsilanyl)oxy]hex-5-en-1-ol 
• 728944-90-9 (2S,3S)-5-(benzyloxy)-2-[(E)-styryl]pentane-1,3-diol 
• 281191-05-7 (3S,4R,5E)-4-methyl-6-phenyl-3-[(triisopropylsilanyl)oxy]hex-5-enal 
• 281190-98-5 (3S,4R,5E)-1-(benzyloxy)-4-methyl-6-phenylhex-5-en-3-ol 

Downstream Products

• 155645-51-5 Cryptophycin 4 
• 162465-18-1 (S)-2-((R)-3-Amino-2-methyl-propionyloxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-1-carboxy-2-(4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester 

Relevant articles and documents

Synthesis of bioactive natural products by asymmetric syn-and anti-aldol reactions

The use of several variants of the asymmetric aldol reaction as key steps in the syntheses of bioactive target molecules is described. Georg Thieme Verlag Stuttgart.

A convergent synthesis of (+)-cryptophycin B, a potent antitumor macrolide from Nostoc sp. cyanobacteria.

[structure--see text] An efficient and highly stereoselective synthesis of cryptophycin B (2), a potent cytotoxic agent, is described. The ester-derived titanium-enolate-mediated syn-aldol reaction was employed to generate the stereocenters C(5) and C(6). The route is convergent and provides a convenient access to the synthesis of structural variants of cryptophycin B as well as members of its family.