281235-00-5

Basic information

• Product Name: Methyl-4-(N-(tert-butoxycarbonyl)-4-piperidinyloxy)benzoate
• Synonyms: Methyl-4-(N-(tert-butoxycarbonyl)-4-piperidinyloxy)benzoate;tert-butyl 4-(4-(methoxycarbonyl)phenoxy)piperidine-1-carboxylate
• CAS NO: 281235-00-5
• Molecular Formula: C₁₈H₂₅NO₅
• Molecular Weight: 335.3948
• Mol File: 281235-00-5.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl-4-(N-(tert-butoxycarbonyl)-4-piperidinyloxy)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl-4-(N-(tert-butoxycarbonyl)-4-piperidinyloxy)benzoate(281235-00-5)
• EPA Substance Registry System: Methyl-4-(N-(tert-butoxycarbonyl)-4-piperidinyloxy)benzoate(281235-00-5)

Safety Data

• Hazardous Substances Data: 281235-00-5(Hazardous Substances Data)

Upstream product

• 99-76-3 methyl 4-hydroxylbenzoate 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 99-75-2 4-methyl-benzoic acid methyl ester 
• 118811-07-7 tert-butyl 4-(tosyloxy)piperidin-1-carboxylate 

Downstream Products

• 162046-56-2 4-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoic acid 
• 455323-66-7 4'-(methoxycarbonylphenyloxy)-4-piperidine hydrochloride 
• 952588-99-7 4-(piperidin-4-yloxy)-benzoic acid methyl ester trifluoroacetate 
• 455323-67-8 methyl 4-(N-(diphenyl)acetyl-4-piperidinyloxy)benzoate 
• 455323-70-3 methyl 4-(N-(diphenyl)carbamoyl-4-piperidinyloxy)benzoate 
• 455323-68-9 methyl 4-(N-adamantanoyl-4-piperidinyloxy)benzoate 
• 99764-63-3 Leu-Ser-p-nitro-Phe-Nle-Ala-Leu-OMe*TFA 
• 281234-95-5 methyl 4-(piperidin-4-yloxy)benzoate 
• 1595145-22-4 4-[(1-{6-[(2S)-2-{[2-(4-cyanophenyl)ethyl]carbamoyl}azetidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}piperidin-4-yl)oxy]benzoic acid 
• 321337-38-6 tert-butyl 4-(4-(hydroxymethyl)phenoxy)piperidine-1-carboxylate 

Relevant articles and documents

TRICYCLIC DEGRADERS OF IKAROS AND AIOLOS

Tricyclic cereblon binders for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway for therapeutic applications are described.

HISTONE DEACETYLASE INHIBTORS

Provided herein are compounds and methods for inhibiting histone deacetylase ("HDAC") enzymes (e.g., HDAC1, HDAC2, and HDAC3).

Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: Structure-activity relationships, lead optimization, and chronic in vivo efficacy

Activation of the G-protein coupled receptor (GPCR) Takeda G-protein receptor 5 (TGR5), also known as G-protein bile acid receptor 1 (GPBAR1), has been shown to play a key role in pathways associated with diabetes, metabolic syndrome, and autoimmune disease. Nipecotamide 5 was identified as an attractive starting point after a high-throughput screen (HTS) for receptor agonists. A comprehensive hit-to-lead effort culminated in the discovery of 45h as a potent, selective, and bioavailable TGR5 agonist to test in preclinical metabolic disease models. In genetically obese mice (ob/ob), 45h was as effective as a dipeptidyl peptidase-4 (DPP-4) inhibitor at reducing peak glucose levels in an acute oral glucose tolerance test (OGTT), but this effect was lost upon chronic dosing.