2816-63-9

Basic information

• Product Name: 2-bromo-2,6,6-trimethylcyclohexanone
• CAS NO: 2816-63-9
• Molecular Formula: C₉H₁₅BrO
• Molecular Weight: 219.1188
• Mol File: 2816-63-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 229°C at 760 mmHg
• Flash Point: 29.2°C
• Density: 1.258g/cm³
• Vapor Pressure: 0.071mmHg at 25°C
• Refractive Index: 1.48
• CAS DataBase Reference: 2-bromo-2,6,6-trimethylcyclohexanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-2,6,6-trimethylcyclohexanone(2816-63-9)
• EPA Substance Registry System: 2-bromo-2,6,6-trimethylcyclohexanone(2816-63-9)

Safety Data

• Hazardous Substances Data: 2816-63-9(Hazardous Substances Data)

Upstream product

• 2408-37-9 2,2,6-trimethylcyclohexan-1-one 
• 83999-44-4 2,6,6-trimethyl-1-trimethylsilyloxycyclohexene 

Downstream Products

• 13155-74-3 2-methoxy-2,6,6-trimethyl-cyclohexanone 
• 20013-73-4 2,6,6-trimethylcyclohex-2-en-1-one 
• 7500-42-7 2-hydroxy-2,2,6-trimethylcyclohexanone 
• 91016-09-0 6-Methylamino-2,2,6-trimethyl-cyclohexanon 

Relevant articles and documents

Facile synthesis of c/s-2-alkyl-3-trialkylsilyloxycycloalkanones via the non-aldol aldol rearrangement of 2,3-epoxycycloalkanols

Silyl triflate-promoted rearrangement of c/s-2,3-epoxycycloalkanols A, prepared by epoxidation of the cyclic allylic alcohol and then sllylatlon, afforded good yields (～70-75%) of the c/s-2-alkyl-3-silyloxycycloalkanones B, presumably via the intermediates C and D, even with quite large α-substituents, e.g., terf-butyl. Finally, it has been shown that the stereochemistry of the epoxy alcohol is crucial as one would expect from the mechanism.