28168-60-7 Usage
Heterocyclic compound
Pyrrole ring
The compound contains a pyrrole ring, which is a five-membered ring with one nitrogen atom and four carbon atoms.
Substituents
Two phenyl groups and a carbonitrile group
The pyrrole ring has two phenyl groups (C6H5) attached to it, which are aromatic rings with delocalized electrons.
A carbonitrile group (C≡N) is also attached to the pyrrole ring, which is a triple-bonded combination of carbon and nitrogen atoms.
Field of application
Organic synthesis and pharmaceutical research
The compound is primarily used in the fields of organic synthesis and pharmaceutical research due to its unique structure and properties.
Potential biological activities
Antitumor and antibacterial properties
2,5-diphenyl-3,4-dihydro-2H-pyrrole-3-carbonitrile has been studied for its potential biological activities, including its ability to inhibit tumor growth and combat bacterial infections.
Building block for complex organic compounds
Synthesis of other compounds
The compound's unique structure and properties make it a valuable building block for the synthesis of various other complex organic compounds, further expanding its applications in research and industry.
Check Digit Verification of cas no
The CAS Registry Mumber 28168-60-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,1,6 and 8 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 28168-60:
(7*2)+(6*8)+(5*1)+(4*6)+(3*8)+(2*6)+(1*0)=127
127 % 10 = 7
So 28168-60-7 is a valid CAS Registry Number.
28168-60-7Relevant articles and documents
[3 + 2] Cycloaddition/Oxidative Aromatization Sequence via Photoredox Catalysis: One-Pot Synthesis of Oxazoles from 2H-Azirines and Aldehydes
Zeng, Ting-Ting,Xuan, Jun,Ding, Wei,Wang, Kuan,Lu, Liang-Qiu,Xiao, Wen-Jing
supporting information, p. 4070 - 4073 (2015/09/01)
A novel [3 + 2] cycloaddition/oxidative aromatization sequence via visible light-induced photoredox catalysis is disclosed. It provides a general synthetic route to 2,4,5-trisubstituted oxazoles from easily accessible 2H-azirines and aldehydes under mild reaction conditions. The potential of this strategy was further demonstrated by the rapid synthesis of a cyclooxygenase-2 inhibitor as well as the success of employing electron-deficient alkenes and imines as the reaction partners.
The synthesis of pyrroles and dihydropyrroles by 1,3-dipolar cyclisations of N-arylmethylene[(benzotriazol-1-yl)arylmethyl]amines
Katritzky,Hitchings,Zhao
, p. 863 - 867 (2007/10/02)
N-Arylmethylene[(benzotriazol-1-yl)arylmethyl]amines 1 are prepared by the reaction of arylaldehydes, benzotriazole, and ammonia in dry ethanol. Deprotonation of these imines with butyllithium yields N-lithiated azomethine ylides 2 which readily undergo 1,3-dipolar cycloaddition with a large range of dipolarophiles. The cyclisations are regiospecific and generally exhibit high stereoselectivity. Benzotriazolate is eliminated during the course of the reaction, and the method thereby provides a route to 2,5-diaryl substituted pyrroles, 3,4-dihydro-2H-pyrroles and c-ring fused 3,4-dihydro-2H-pyrroles.
