2819-12-7Relevant articles and documents
Asymmetric Michael addition reactions using a chiral La-Na aminodiolate catalyst
Prabagaran,Sundararajan
, p. 1053 - 1058 (2002)
(R,R)-(+)-2-[Benzyl-(2-hydroxy-2-phenylethyl)amino]-1-phenylethanol 1 is used as a chiral ligand in the synthesis of an optically active lanthanum-sodium amino diol complex LS-1. This heterobimetallic catalyst is quite effective as an asymmetric catalyst for various Michael addition reactions, 1H NMR study indicates the co-ordination of enone to the central lanthanum atom in LS-1. The reaction conditions were optimized and the adducts were obtained in high yield with moderate to high enantiomeric excess under extremely mild conditions.
Selective C-C Bond Scission of Ketones via Visible-Light-Mediated Cerium Catalysis
Chen, Yilin,Du, Jianbo,Zuo, Zhiwei
supporting information, p. 266 - 279 (2020/01/08)
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α-Diazo-β-ketonitriles: Uniquely reactive substrates for arene and alkene cyclopropanation
Nani, Roger R.,Reisman, Sarah E.
supporting information, p. 7304 - 7311 (2013/06/27)
An investigation of the intramolecular cyclopropanation reactions of α-diazo-β-ketonitriles is reported. These studies reveal that α-diazo-β-ketonitriles exhibit unique reactivity in their ability to undergo arene cyclopropanation reactions; other similar acceptor-acceptor- substituted diazo substrates instead produce mixtures of C-H insertion and dimerization products. α-Diazo-β-ketonitriles also undergo highly efficient intramolecular cyclopropanation of tri- and tetrasubstituted alkenes. In addition, the α-cyano-α-ketocyclopropane products are demonstrated to serve as substrates for SN2, SN2′, and aldehyde cycloaddition reactions.