28193-70-6

Basic information

• Product Name: Benzeneacetamide, a-oxo-N-(phenylmethyl)-
• CAS NO: 28193-70-6
• Molecular Formula: C15H13NO2
• Molecular Weight: 239.274
• Mol File: 28193-70-6.mol
• Article Data: 50

Chemical Properties

• CAS DataBase Reference: Benzeneacetamide, a-oxo-N-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetamide, a-oxo-N-(phenylmethyl)-(28193-70-6)
• EPA Substance Registry System: Benzeneacetamide, a-oxo-N-(phenylmethyl)-(28193-70-6)

Safety Data

• Hazardous Substances Data: 28193-70-6(Hazardous Substances Data)

Upstream product

• 4410-32-6 N-benzyl-2-hydroxy-2-phenylacetamide 
• 2446-83-5 di-isopropyl azodicarboxylate 
• 100-46-9 benzylamine 
• 60-12-8 2-phenylethanol 
• 1005500-75-3 N-(methyl)-N-(p-toluenesulfonyl)ethynylamine 
• 611-73-4 Benzoylformic acid 
• 1357012-16-8 N-ethynyl-N-phenyl-methanesulfonamide 
• 660866-29-5 3-ethynyl-1,3-oxazolidin-2-one 
• 1345669-04-6 N-allyl-N-benzyl-2-oxo-2-phenylacetamide 
• 1345668-87-2 N-allyl-2-azido-N-benzyl-2-phenylacetamide 
• 15206-55-0 methyl 2-oxo-2-phenylacetate 
• 25726-04-9 phenylglyoxylyl chloride 
• 127616-16-4 4-phenyl-5H-1,2,3-dithiazole-5-one 
• 611-71-2 MANDELIC ACID 

Downstream Products

• 4410-32-6 N-benzyl-2-hydroxy-2-phenylacetamide 
• 70183-68-5 3-hydroxy-3,4-diphenylazetidin-2-one 
• 88393-58-2 (R)-N-benzyl-2-hydroxy-2-phenylacetamide 
• 82270-62-0 (S)-N-benzylmandelamide 
• 95504-91-9 {IrH((C₃H₇)2P(CH₂)3P(C₃H₇)2)(OCHC₆H₅C(O)NHCH₂C₆H₅)}⁽¹⁺⁾*PF₆^(1-)={IrH((C₃H₇)2P(CH₂)3P(C₃H₇)2)(OCH(C₆H₅)C(O)NHCH₂C₆H₅)}PF₆ 
• 7500-45-0 N-benzylphenylacetamide 
• 51096-49-2 2-benzylamino-1-phenyl-ethanol 
• 117416-53-2 3-benzyl-5-phenyloxazolidin-2-one 

Relevant articles and documents

One-Pot Synthesis of α-Ketoamides from α-Keto Acids and Amines Using Ynamides as Coupling Reagents

A one-pot strategy for α-keto amide bond formation have been developed by using ynamides as coupling reagents under extremely mild reaction conditions. Diversely structural α-ketoamides were afforded in up to 98% yield for 36 examples. This reaction features advantages such as practical coupling procedure, wide functional group tolerance, and extremely mild conditions and has potential applications in synthetic and medicinal chemistry.

Selective electrochemical oxidation of aromatic hydrocarbons and preparation of mono/multi-carbonyl compounds

A selective electrochemical oxidation was developed under mild condition. Various mono-carbonyl and multi-carbonyl compounds can be prepared from different aromatic hydrocarbons with moderate to excellent yield and selectivity by virtue of this electrochemical oxidation. The produced carbonyl compounds can be further transformed into α-ketoamides, homoallylic alcohols and oximes in a one-pot reaction. In particular, a series of α-ketoamides were prepared in a one-pot continuous electrolysis. Mechanistic studies showed that 2,2,2-trifluoroethan-1-ol (TFE) can interact with catalyst species and generate the corresponding hydrogen-bonding complex to enhance the electrochemical oxidation performance. [Figure not available: see fulltext.]

Electrochemical Synthesis of α-Ketoamides under Catalyst-, Oxidant-, and Electrolyte-Free Conditions

A catalyst-, oxidant-, electrolyte-free method for the preparation of α-ketoamides through the direct electrochemical amidation of α-ketoaldehydes and amines with innocuous hydrogen as the sole byproduct at ambient temperature was developed. The present reaction features clean and mild conditions, excellent functional-group tolerance, and high atom economy and scalability, enabling facile applications in pharmaceutical chemistry.