2820-55-5 Usage
Description
(2'S)-Nicotine 1-Oxide is a metabolite of nicotine, which is formed when nicotine undergoes metabolism in the liver by the cytochrome P450 (CYP) isoform CYP2A6. It has been detected in human sperm and semen and is characterized by its light yellow crystalline appearance. As a member of the class of pyridine N-oxides, it is obtained by the oxidation of the pyridine nitrogen of (S)-nicotine.
Uses
Used in Medical Research:
(2'S)-Nicotine 1-Oxide is used as a biomarker for bladder cancer in humans. The ratio of this metabolite to cotinine, another metabolite of nicotine, has been suggested as an indicator for the presence of bladder cancer.
Used in Pharmaceutical Industry:
(2'S)-Nicotine 1-Oxide is used as an intermediate compound in the synthesis of various nicotine-derived drugs. Its unique properties and metabolic origin make it a valuable compound for research and development in the pharmaceutical sector.
Used in Toxicology Studies:
(2'S)-Nicotine 1-Oxide is used as a subject of study in toxicology to understand the effects of nicotine and its metabolites on human health, particularly in the context of smoking and exposure to tobacco products.
Used in Analytical Chemistry:
(2'S)-Nicotine 1-Oxide serves as a reference compound in analytical chemistry for the development and validation of methods to detect and quantify nicotine and its metabolites in biological samples, such as blood, urine, and tissue.
Check Digit Verification of cas no
The CAS Registry Mumber 2820-55-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,8,2 and 0 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 2820-55:
(6*2)+(5*8)+(4*2)+(3*0)+(2*5)+(1*5)=75
75 % 10 = 5
So 2820-55-5 is a valid CAS Registry Number.
InChI:InChI=1/C10H14N2O/c1-11-6-3-5-10(11)9-4-2-7-12(13)8-9/h2,4,7-8,10H,3,5-6H2,1H3
2820-55-5Relevant articles and documents
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Phillipson,Handa
, p. 2683 (1975)
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6-Pyridylnicotine and bis-6,6'-nicotine - new chiral 2,2'-bipyridines
Schmidt, Boris,Neitemeier, Vera
, p. 42 - 44 (2007/10/03)
Starting from (-)-nicotine, two new 2,2'-bipyridine ligands 6 and 7 with chiral pyrrolidine side chains have been synthesized. The stoichiometric complexation by palladium(II) or mercury(II) ions gives the bipyridyl complexes 8 and 9.
