28215-42-1

Basic information

• Product Name: Methanone, (3-hydroxy-2-naphthalenyl)phenyl-
• CAS NO: 28215-42-1
• Molecular Formula: C17H12O2
• Molecular Weight: 248.281
• Mol File: 28215-42-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Methanone, (3-hydroxy-2-naphthalenyl)phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (3-hydroxy-2-naphthalenyl)phenyl-(28215-42-1)
• EPA Substance Registry System: Methanone, (3-hydroxy-2-naphthalenyl)phenyl-(28215-42-1)

Safety Data

• Hazardous Substances Data: 28215-42-1(Hazardous Substances Data)

Upstream product

• 53855-64-4 3-acetoxy-2-naphthoyl chloride 
• 71-43-2 benzene 
• 1734-00-5 3-hydroxy-2-naphthoyl chloride 
• 93-44-7 2-naphthyl benzoate 
• 581-71-5 2-Hydroxy-3-naphthaldehyde 
• 43029-63-6 3-methoxy-2-naphthyl phenyl ketone 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 98-88-4 benzoyl chloride 
• 1743-36-8 1-phenylbut-3-yn-1-ol 
• 93-91-4 1-phenylbutan-1,3-dione 
• 92-70-6 3-Hydroxy-2-naphthoic acid 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 68376-08-9 phenyl(3-phenylnaphthalen-2-yl)methanone 

Relevant articles and documents

Synthesis of Polysubstituted 2-Naphthols by Palladium-Catalyzed Intramolecular Arylation/Aromatization Cascade

A palladium-catalyzed intramolecular α-arylation and defluorinative aromatization strategy for the synthesis of polysubstituted 2-naphthols is reported. With ortho-bromobenzyl-substituted α-fluoroketones as the substrates and palladium acetate/triphenylphosphine as the catalyst, this method features good functional group tolerance, readily available catalyst and starting materials, and high yields. The applications of the strategy are demonstrated by the synthesis of useful building blocks, such as naphtha[2,3-b]furan, naphthol AS-D, and ligands/catalysts. (Figure presented.).

De Novo Synthesis of Phenols and Naphthols through Oxidative Cycloaromatization of Dienynes

In this work, a rhodium-catalyzed oxidative cycloaromatization of dienynes, which provides a highly straightforward and efficient way to access polysubstituted naphthols and phenols under mild conditions, is described. Challenged electron-withdrawing groups are well tolerated in this protocol, and late-stage phenyl ring formation is demonstrated.

Enantioselective oxidative biaryl coupling reactions catalyzed by 1,5-diazadecalin metal complexes: Efficient formation of chiral functionalized BINOL derivatives

Chiral 1,5-diaza-cis-decalins have been examined as ligands in the enantioselective oxidative biaryl coupling of substituted 2-naphthol derivatives. Under the optimal conditions employing 2.5-10 mol % of a 1,5-diaza-cis-decalin copper(II) catalyst with oxygen as the oxidant, enantioselective couplings (44-96% ee) could be achieved for a range of 3-substituted 2-naphthols including the ester, ketone, phosphonyl, and sulfonyl derivatives. The relationship between the substitution of the naphthalene starting materials and reactivity/selectivity is determined by several factors which act in concert: (1) the effect of substituents on the oxidation potential of the substrate, (2) the ability of the substrate to participate in a chelated copper complex which depends on (a) the inherent coordinating ability of the 3-substituent and (b) substituent steric interactions that affect chelation between the 2-hydroxyl and 3-substituent, (3) the effect of substituents on dissociation of the product from the copper catalyst.