28217-95-0

Basic information

• Product Name: Pyrazine, 2-(phenylMethyl)-
• Synonyms: Pyrazine, 2-(phenylMethyl)-
• CAS NO: 28217-95-0
• Molecular Formula: C₁₁H₁₀N₂
• Molecular Weight: 170.2105
• Mol File: 28217-95-0.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Pyrazine, 2-(phenylMethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrazine, 2-(phenylMethyl)-(28217-95-0)
• EPA Substance Registry System: Pyrazine, 2-(phenylMethyl)-(28217-95-0)

Safety Data

• Hazardous Substances Data: 28217-95-0(Hazardous Substances Data)

Usage

General Description

Pyrazine, 2-(phenylMethyl)- is a chemical compound with the formula C13H12N2. It is a colorless to pale yellow liquid with a strong, nutty odor. Due to its aromatic and spicy scent, it is commonly used as a flavoring agent in the food industry, particularly in the production of chocolate and coffee flavored products. It is also utilized in the manufacture of fragrances and pharmaceuticals. Additionally, it has potential applications in the synthesis of organic compounds and as a building block in the development of new materials. Despite its versatile uses, it is important to handle this chemical with care and follow safety guidelines due to its potential hazards.

Upstream product

• 90210-53-0 2-benzylpyrazine N₁-oxide 
• 62673-31-8 benzyl(bromo)zinc 
• 21948-70-9 2-(methylthio)pyrazine 
• 108-90-7 chlorobenzene 
• 140-29-4 phenylacetonitrile 
• 108-86-1 bromobenzene 
• 1251919-99-9 potassium 2-(pyrazin-2-yl)acetate 
• 100-59-4 phenylmagnesium chloride 
• 5780-66-5 pyrazinecarboxaldehyde 
• 98792-43-9 (α-hydroxybenzyl)pyrazine 
• 100-52-7 benzaldehyde 

Downstream Products

• 90210-53-0 2-benzylpyrazine N₁-oxide 
• 90210-59-6 3-Benzylpyrazine 1-oxide 
• 126474-01-9 α-bromo-α-phenylmethylpyrazine 
• 126474-02-0 8-Phenyl-5,8-dihydro-6H-pyrano[3,4-b]pyridine 
• 126474-03-1 1-Phenyl-3,4-dihydro-1H-pyrano[3,4-c]pyridine 
• 126473-95-8 α-phenyl-α-(3-butynyloxy)methylpyrazine 
• 126474-17-7 1-Phenyl-5-trimethylsilanyl-3,4-dihydro-1H-pyrano[3,4-c]pyridine 
• 126474-16-6 8-Phenyl-4-trimethylsilanyl-5,8-dihydro-6H-pyrano[3,4-b]pyridine 
• 126474-10-0 2-[Phenyl-(4-trimethylsilanyl-but-3-ynyloxy)-methyl]-pyrazine 

Relevant articles and documents

Mild Condition for the Deoxygenation of α-Heteroaryl-Substituted Methanol Derivatives

A mild condition via PPh3/I2/imidazole for the deoxygenation of substituted methanol derivatives has been identified. This metal-free process was found to proceed well on secondary or tertiary alcohols substituted with one or two heteroaryl groups, and it tolerates acid-sensitive heterocycles. This condition works for methanol derivatives substituted with 2-pyridyl, 4-pyridyl, or other heterocyclic groups, allowing the negative charge formed during the reaction to resonate to a nitrogen atom. Methanol derivatives substituted with 3-pyridyl or heterocyclic groups that do not allow the negative charge formed during the reaction to resonate to a nitrogen atom will not undergo deoxygenation under this condition.

PBr3-mediated unexpected reductive deoxygenation of α-aryl-pyridinemethanols: Synthesis of arylmethylpyridines

PBr3-mediated reductive deoxygenation of α-aryl-pyridinemethanols to provide arylmethylpyridines is described, the alcohol substrate scope is explored, free radical trap TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxy) is introduced, and the hydrogen source of the methylene product is defined. The unexpected reaction enabled us to prepare previously inaccessible, novel EP1 antagonists.

PYRIMIDINONE DERIVATIVES AND METHODS OF USE THEREOF

The present invention relates to Pyrimidinone Derivatives, compositions comprising a Pyrimidinone Derivative, and methods of using the Pyrimidinone Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of G protein-coupled receptor 119 ("GPR119") in a patient.