28252-46-2

Basic information

• Product Name: CARBOBENZYLOXYTYROSYLTYROSINE METHYL ESTER
• Synonyms: CARBOBENZYLOXYTYROSYLTYROSINE METHYL ESTER
• CAS NO: 28252-46-2
• Molecular Formula: C₂₇H₂₈N₂O₇
• Molecular Weight: 492.52042
• Mol File: 28252-46-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: CARBOBENZYLOXYTYROSYLTYROSINE METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: CARBOBENZYLOXYTYROSYLTYROSINE METHYL ESTER(28252-46-2)
• EPA Substance Registry System: CARBOBENZYLOXYTYROSYLTYROSINE METHYL ESTER(28252-46-2)

Safety Data

• Hazardous Substances Data: 28252-46-2(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 10417-83-1 N-(N-benzyloxycarbonyl-L-tyrosyl)-L-tyrosine 
• 1164-16-5 Z-L-Tyr-OH 
• 3417-91-2 L-tyrosine methyl ester HCl 

Downstream Products

• 13022-41-8 L-tyrosyl-L-tyrosine methyl ester 
• 10125-11-8 cis-3,6-bis(4-hydroxybenzyl)piperazine-2,5-dione 

Relevant articles and documents

Tandem deprotection/coupling for peptide synthesis in water at room temperature

A tandem deprotection/coupling sequence is reported for solution-phase peptide synthesis in water under micellar catalysis conditions using the designer surfactant TPGS-750-M. Cbz deprotection followed by peptide coupling in the presence of COMU and 2,6-lutidine afforded polypeptides containing up to 10 amino acid residues. A broad scope characterizes this new technology. No epimerization has been detected. The associated E Factors, as a measure of "greenness" and known to be extremely high for peptide couplings, have been reduced to less than 10 due to the step-economy and minimal amounts of organic solvent needed for product extraction.