282727-20-2

Basic information

• Product Name: 2-METHOXYPHENYLZINC IODIDE 0.5M
• Synonyms: 2-METHOXYPHENYLZINC IODIDE 0.5M;2-METHOXYPHENYLZINC IODIDE, 0.5M SOLUTIO N IN TETRAHYDROFURAN;2-methoxyphenylzinc iodide solution;2-Methoxyphenylzinc iodide solution 0.5 in THF;2-Methoxyphenylzinc iodide, 0.5M in THF, packaged under Argon in resealable CheMSeal^t bottles;2-Methoxyphenylzinc iodide, 0.5M in THF, packaged under Argon in resealable ChemSeal™2-Methoxyphenylzinc iodide, Packaged under Argon in resealable ChemSeal? bottles;2-Methoxyphenylzinc iodide solution 0.5M in THF
• CAS NO: 282727-20-2
• Molecular Formula: C₇H₇IOZn
• Molecular Weight: 299.42435
• Product Categories: Aryl;Organozinc Halides;Reike and Organozinc Reagents
• Mol File: 282727-20-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: 1 °F
• Appearance: /
• Density: 0.996 g/mL at 25 °C
• Storage Temp.: 2-8°C
• Sensitive: Air & Light Sensitive
• CAS DataBase Reference: 2-METHOXYPHENYLZINC IODIDE 0.5M(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXYPHENYLZINC IODIDE 0.5M(282727-20-2)
• EPA Substance Registry System: 2-METHOXYPHENYLZINC IODIDE 0.5M(282727-20-2)

Safety Data

• Hazard Codes: F,Xn
• Statements: 19-22-36/38-40-36/37-14-11
• Safety Statements: 16-26-33-36-36/37
• RIDADR: UN 2056 3/PG 2
• WGK Germany: 1
• HazardClass: 4.3
• Hazardous Substances Data: 282727-20-2(Hazardous Substances Data)

Usage

Description

2-METHOXYPHENYLZINC IODIDE 0.5M is an organometallic compound that consists of a zinc atom bonded to a 2-methoxyphenyl group and an iodide ion. It is a reagent used in various chemical reactions due to its unique properties and reactivity.

Uses

Used in Chemical Synthesis:
2-METHOXYPHENYLZINC IODIDE 0.5M is used as a substrate for the synthesis of aryl ketones by reacting with aroyl chlorides. This application is valuable in the production of various organic compounds and pharmaceuticals, as aryl ketones serve as important intermediates in the synthesis of a wide range of molecules.
Used in Synthesis of Sulfone Compounds:
2-METHOXYPHENYLZINC IODIDE 0.5M is used as a starting material in the synthesis of sulfones by reacting with DABSO reagent and alkyl halides. Sulfone compounds are important in various industries, including pharmaceuticals, agrochemicals, and materials science, due to their unique properties and applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-METHOXYPHENYLZINC IODIDE 0.5M is used as a key intermediate in the synthesis of various drug molecules. Its reactivity and versatility make it a valuable tool for the development of new medications and therapeutic agents.
Used in Material Science:
In the field of material science, 2-METHOXYPHENYLZINC IODIDE 0.5M is used as a precursor for the development of novel materials with specific properties. Its ability to form aryl ketones and sulfones can lead to the creation of new polymers, coatings, and other materials with unique characteristics.

Upstream product

• 529-28-2 4-iodoanisol 
• 7440-66-6 zinc 

Downstream Products

• 188824-70-6 4-(2-Methoxy-phenyl)-4H-pyridine-1-carboxylic acid phenyl ester 
• 5957-89-1 2-(2-methoxy-phenyl)-pyridine 
• 1062517-78-5 (R)-(3-(2-methoxyphenyl)hept-1-yn-1-yl)trimethylsilane 
• 122547-45-9 (2,6-dimethoxyphenyl)(2-methoxyphenyl)methanone 
• 4885-13-6 (2,4,6-trimethylphenyl)(2-methoxyphenyl)methanone 
• 1268821-22-2 (2,6-difluorophenyl)(2-methoxyphenyl)methanone 
• 1504589-23-4 tert-butyl 2-((2-methoxyphenyl)sulfonyl)acetate 
• 850570-34-2 N-(cyclohexylamino)-o-anisidine 
• 100-66-3 methoxybenzene 
• 113547-30-1 2’-methoxy-[1,1’-biphenyl]-4-carbonitrile 
• 86-26-0 2-methoxy-1,1'-biphenyl 

Relevant articles and documents

Rhodium-Catalyzed Addition of Organozinc Iodides to Carbon-11 Isocyanates

Amides were prepared using rhodium-catalyzed coupling of organozinc iodides and carbon-11 (11C, t1/2 = 20.4 min) isocyanates. Nonradioactive isocyanates and sp3 or sp2 organozinc iodides generated amides in yields of 13%-87%. Incorporation of cyclotron-produced [11C]CO2 into 11C-amide products proceeded in yields of 5%-99%. The synthetic utility of the methodology was demonstrated through the isolation of [11C]N-(4-fluorophenyl)-4-methoxybenzamide ([11C]6g) with a molar activity of 267 GBq μmol-1 and 12% radiochemical yield in 21 min from the beginning of synthesis.

Mechanochemical Activation of Zinc and Application to Negishi Cross-Coupling

A form independent activation of zinc, concomitant generation of organozinc species and engagement in a Negishi cross-coupling reaction via mechanochemical methods is reported. The reported method exhibits a broad substrate scope for both C(sp3)–C(sp2) and C(sp2)–C(sp2) couplings and is tolerant to many important functional groups. The method may offer broad reaching opportunities for the in situ generation organometallic compounds from base metals and their concomitant engagement in synthetic reactions via mechanochemical methods.

Ni-Catalyzed Regioselective Dicarbofunctionalization of Unactivated Olefins by Tandem Cyclization/Cross-Coupling and Application to the Concise Synthesis of Lignan Natural Products

We disclose a (terpy)NiBr2-catalyzed reaction protocol that regioselectively difunctionalizes unactivated olefins with tethered alkyl halides and arylzinc reagents. The reaction shows an excellent functional group tolerance (such as ketones, es