2833-68-3

Basic information

• Product Name: Benzaldehyde, (4-chlorophenyl)hydrazone
• CAS NO: 2833-68-3
• Molecular Formula: C13H11ClN2
• Molecular Weight: 230.697
• Mol File: 2833-68-3.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, (4-chlorophenyl)hydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, (4-chlorophenyl)hydrazone(2833-68-3)
• EPA Substance Registry System: Benzaldehyde, (4-chlorophenyl)hydrazone(2833-68-3)

Safety Data

• Hazardous Substances Data: 2833-68-3(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 1073-69-4 N-4-chlorophenylhydrazine 
• 100-39-0 benzyl bromide 
• 2725-46-4 1-benzyl-2-benzylidene-1-phenylhydrazine 
• 588-64-7 benzaldehyde phenylhydrazone 
• 106-47-8 4-chloro-aniline 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 

Downstream Products

• 58429-88-2 1,5-bis-(4-chloro-phenyl)-3-phenyl-formazan 
• 25939-21-3 N'-(2,4-dichloro-phenyl)-benzohydrazonoyl chloride 
• 142397-33-9 1-(4-Chlorphenyl)-3-phenyl<1,2,4>triazolo<4,3-a>pyridinium-perchlorat 
• 1223079-56-8 4-ethyl(carbethoxy)amino-2-(4-chlorophenyl)-5-phenyl-2H-1,2,4-triazol-3(4H)-one 
• 35188-64-8 1-benzyl-2-benzylidene-1-(4-chlorophenyl)hydrazine 
• 17355-68-9 1-(4-chlorophenyl)-3,5-diphenyl-1H-1,2,4-triazole 
• 17359-82-9 N-(α-chlorobenzylidene)-N'-p-chlorophenylhydrazine 
• 1346003-68-6 ethyl 1-(4-chlorophenyl)-5-methyl-3-phenyl-1H-pyrazole-4-carboxylate 
• 104-88-1 4-chlorobenzaldehyde 
• 63637-57-0 1-(4-chlorophenyl)-3-phenyl-1H-pyrazole 
• 100-52-7 benzaldehyde 
• 18411-24-0 2-(4-chlorophenyl)-4,5-diphenyl-2H-1,2,3-triazole 

Relevant articles and documents

Broad-Spectrum Antifungal Agents: Fluorinated Aryl- and Heteroaryl-Substituted Hydrazones

Fluorinated aryl- and heteroaryl-substituted monohydrazones displayed excellent broad-spectrum activity against various fungal strains, including a panel of clinically relevant Candida auris strains relative to a control antifungal agent, voriconazole (VRC). These monohydrazones displayed less hemolysis of murine red blood cells than that of VRC at the same concentrations, possessed fungicidal activity in a time-kill study, and exhibited no mammalian cell cytotoxicity. In addition, these monohydrazones prevented the formation of biofilms that otherwise block antibiotic effectiveness and did not trigger the development of resistance when exposed to C. auris AR Bank # 0390 over 15 passages.

Mn(III)-mediated phosphinoylation of aldehyde hydrazones: Direct “one-pot” synthesis of α-iminophosphine oxides from aldehydes

A “one-pot” strategy for the straightforward Mn(III)-mediated phosphinoylation of aldehyde hydrazones with diphenylphosphine oxide to furnish α-iminophosphine oxides is described. This mild and practical method allows the direct use of aldehydes as substrates in one pot to generate the hydrazones, which are then engaged “in situ” by the phosphorus reagent in the presence of Mn(OAc)3 oxidant. Thus, the requisite isolation of the hydrazones is not needed in this operation. Conducted mechanistic experiments implicate a pathway involving phosphorus-centered radicals.

Stereospecific copper(II)-catalyzed tandem ring opening/oxidative alkylation of donor-acceptor cyclopropanes with hydrazones: Synthesis of tetrahydropyridazines

Aerobic copper(II)-catalyzed tandem ring opening and oxidative C-H alkylation of donor-acceptor cyclopropanes with bisaryl hydrazones is accomplished to produce tetrahydropyridazines, in which copper(II) plays dual role as a Lewis acid as well as redox catalyst. The reaction is stereospecific, and optically active cyclopropanes can be reacted with high optical purities (89-98% enantiomeric excess). The substrate scope, functional group tolerance, dual role of the copper(II) catalyst, and the use of air as an oxidant are the important practical features. A product bearing a 3-bromoaryl group can be subjected to Pd-catalyzed Suzuki coupling with boronic acid in high yield.