28334-65-8

Basic information

• Product Name: Z-S-Pro-S-Val-S-Pro-OtBu
• CAS NO: 28334-65-8
• Molecular Weight: 501.623
• Mol File: 28334-65-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Z-S-Pro-S-Val-S-Pro-OtBu(CAS DataBase Reference)
• NIST Chemistry Reference: Z-S-Pro-S-Val-S-Pro-OtBu(28334-65-8)
• EPA Substance Registry System: Z-S-Pro-S-Val-S-Pro-OtBu(28334-65-8)

Safety Data

• Hazardous Substances Data: 28334-65-8(Hazardous Substances Data)

Upstream product

• 147-85-3 L-proline 
• 5497-76-7 L-proline tert-butyl ester hydrochloride 
• 21285-27-8 (2S)-2-[({(2S)-1-[(benzyloxy)carbonyl]tetrahydro-1H-pyrrol-2-yl}carbonyl)amino]-3-methylbutanoic acid 

Relevant articles and documents

STUDIES ON AMINO ACIDS AND PEPTIDES X. HPLC-MEDIATED TEST OF 2,4-BIS(4-METHOXYPHENYL)-1,3,2,4-DITHIADIPHOSPHETANE 2,4-DISULFIDE (LAWESSONS'S REAGENT) AS A RACEMIZATIONFREE COUPLING REAGENT IN PEPTIDE SYNTHESIS

The easily available 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide (Lawesson's Reagent), 1, has been tested as a coupling reagent for racemization in peptide synthesis.The assay procedure is separation of stereomeric products by HPLC.Z-S-Pro-S-Val-S-Pro-OtBu and Z-S-Leu-S-Phe-S-Val-OtBu have been used as test peptides in 2+1 segment couplings, and only a small amount of epimerization (0.5 and 0.1percent, respectively) has been observed.