2836-03-5Relevant articles and documents
Two-photon "caging" groups: Effect of position isomery on the photorelease properties of aminoquinoline-derived photolabile protecting groups
Tran, Christine,Gallavardin, Thibault,Petit, Morgane,Slimi, Riadh,Dhimane, Hamid,Blanchard-Desce, Mireille,Acher, Francine C.,Ogden, David,Dalko, Peter I.
, p. 402 - 405 (2015)
High two-photon photolysis cross sections and water solubility of probes are important to avoid toxicity in biomedical applications of photolysis. Systematic variation of the position of a carboxyl electron-withdrawing group (EWG) on photolysis of 8-dimet
Tert-amino effect-promoted rearrangement of aryl isothiocyanate: A versatile approach to benzimidazothiazepines and benzimidazothioethers
Geng, Xinyu,Liu, Siyuan,Qu, Jingping,Wang, Baomin,Wang, Wenyao
, p. 12635 - 12643 (2020/11/09)
A general and practical approach to benzimidazothiazepine and benzimidazothioether derivatives via an intramolecular nucleophilic addition/ring expansion rearrangement of aryl isothiocyanates promoted by the tert-amino effect has been developed. This reaction is catalyzed by low-cost camphorsulfonic acid and tolerates a broad substrate scope with complete atom economy. Structurally intriguing benzimidazothiazepine and benzimidazothioether products could be easily obtained by a simple operation in good to excellent yield (up to 98%).
A 3-fluoro-N-dimethyl O-phenylenediamine method for the synthesis of
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Paragraph 0021, (2017/04/19)
The invention discloses a synthesis method of 3-fluoro-N-dimethyl o-phenylenediamine. The method comprises the following steps: with ortho-nitroaniline as a raw material, carrying out base catalysis on o-phenylenediamine and diethyl sulfate at the molar ratio of 1 to 2 by virtue of sodium bicarbonate for 2 hours at the pH value of 8 and the reaction temperature of 20-22 DEG C, so as to prepare N-dimethyl o-phenylenediamine; enabling N-dimethyl o-phenylenediamine to fully react with a fluoride solution under the action of a Pt/C catalyst; and washing, carrying out phase splitting and reduced pressure desolventizing, and drying to obtain 3-fluoro-N-dimethyl o-phenylenediamine, wherein the yield reaches over 87%.