284035-51-4Relevant articles and documents
Synthetic studies on spongistatins: Synthesis of the C29-C44 fragment
Samadi, Mohammad,Munoz-Letelier, Christian,Poigny, Stéphane,Guyot, Michèle
, p. 3349 - 3353 (2007/10/03)
A convergent synthesis of the C29-C44 fragment, the common subunit of the spongipyran macrolides is described. The key step of the synthesis is the C-glycosidation reaction which is based on coupling of the lithiated F-ring sulfone with the E-ring aldehyde, and subsequent reductive desulfonylation to afford the E-F bis (pyran) with high stereoselectivity at the anomeric carbon. (C) 2000 Elsevier Science Ltd.