28444-97-5 Usage
Chemical class
Pregnane steroids
Derivative of
Pregnenolone
Precursor to
Various steroid hormones in the body
Structural modifications
a. Epoxy group at the 16th and 17th positions
b. Acetoxy group at the 21st position
Impact of modifications
Can alter biological activity and pharmacological properties
Potential applications
a. Development of novel steroid-based drugs
b. Research tool for studying steroid hormone pathways and functions
Field of interest
Pharmacology and medicinal chemistry
Check Digit Verification of cas no
The CAS Registry Mumber 28444-97-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,4,4 and 4 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 28444-97:
(7*2)+(6*8)+(5*4)+(4*4)+(3*4)+(2*9)+(1*7)=135
135 % 10 = 5
So 28444-97-5 is a valid CAS Registry Number.
InChI:InChI=1/C23H32O5/c1-13(24)27-12-19(26)23-20(28-23)11-18-16-5-4-14-10-15(25)6-8-21(14,2)17(16)7-9-22(18,23)3/h4,15-18,20,25H,5-12H2,1-3H3/t15-,16+,17-,18-,20-,21-,22-,23+/m0/s1
28444-97-5Relevant articles and documents
Synthesis and cytotoxic effect of pregnenolone derivatives with one or two α,β-unsaturated carbonyls and an ester moiety at C-21 or C-3
Chávez-Riveros, Alejandra,Cruz Noriega, Abigail,Ramírez Apan, María Teresa,Miranda, Luis D.,Bratoeff, Eugene
, p. 37 - 45 (2018)
Four series of pregnenolone derivatives having one or two α,β-unsaturated carbonyls and an ester moiety at C-21 or C-3 were synthetized to compare their cytotoxicity effect. The final compounds were evaluated on three human cancer cell lines: PC-3 (prostate cancer), MCF-7 (breast cancer), SKLU-1 (lung cancer) and a noncancerous cell line HGF (human gingival fibroblast). Two steroids with a 4-fluorinated benzoic acid ester at C-21 were the most active against lung cancer cell line with IC50 of 13.1 ± 1.2 and 12.8 ± 0.5 μM and showed a low percentage of cytotoxicity for noncancerous cells (27.63 ± 2.3 and 18.39 ± 1.2% in the screening at 50 μM).