284462-87-9

Basic information

• Product Name: 4-[(4-aminophenylthio)(2-pyridyl)]-N-methylcarboxamide
• Synonyms: 4-[(4-aminophenylthio)(2-pyridyl)]-N-methylcarboxamide
• CAS NO: 284462-87-9
• Molecular Weight: 259.332
• Mol File: 284462-87-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-[(4-aminophenylthio)(2-pyridyl)]-N-methylcarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(4-aminophenylthio)(2-pyridyl)]-N-methylcarboxamide(284462-87-9)
• EPA Substance Registry System: 4-[(4-aminophenylthio)(2-pyridyl)]-N-methylcarboxamide(284462-87-9)

Safety Data

• Hazardous Substances Data: 284462-87-9(Hazardous Substances Data)

Upstream product

• 24484-93-3 4-Chloro-pyridine-2-carboxylic acid methyl ester 
• 53750-66-6 4-chloro-pyridine-2-carbonyl chloride 
• 98-98-6 2-Picolinic acid 
• 882167-77-3 4-chloro-N-methyl-pyridine-2-carboxamide hydrochloride 
• 1193-02-8 4-aminotiophenol 
• 220000-87-3 4-chloro-N-methylpicolinamide 

Downstream Products

• 1061639-58-4 C₂₃H₂₂N₄O₅S 
• 1061639-23-3 C₂₃H₂₁ClN₄O₅S 
• 1061639-59-5 C₂₁H₁₇N₅O₅S 
• 1061639-63-1 C₂₁H₁₈N₄O₂S₂ 
• 1061639-61-9 C₂₁H₁₈N₄O₃S 
• 1071534-78-5 4-(4-(4-(4-chlorophenyl)phthalazin-1-ylamino)phenylthio)-N-methylpicolinamide 
• 1393482-50-2 4-(4-(2,2-dichloroacetamido)phenylthio)-N-methylpicolinamide 
• 1393482-54-6 N-methyl-4-(4-propionamidophenylthio)picolinamide 
• 1313174-90-1 N-methyl-4-(4-pivalamidophenylthio)picolinamide 
• 1393482-43-3 4-(4-(2-chlorobenzamido)phenylthio)-N-methylpicolinamide 
• 1291103-20-2 4-(4-(3-methoxybenzamido)phenylthio)-N-methylpicolinamide 
• 1291103-22-4 N-methyl-4-(4-(3-(trifluoromethyl)benzamido)phenylthio)picolinamide 
• 1291103-25-7 N-methyl-4-(4-(4-(trifluoromethyl)benzamido)phenylthio)picolinamide 
• 1393482-40-0 4-(4-benzamidophenylthio)-N-methylpicolinamide 

Relevant articles and documents

Thiourea and thioether derivatives of sorafenib: Synthesis, crystal structure, and antiproliferative activity

A series of novel sorafenib derivatives containing diaryl thiourea and thioether, 9a-u, was designed and synthesized, and their antiproliferative activities against HCT116 and MDA-MB-231 cell lines were also evaluated and described. Most compounds exhibited potent antiproliferative activity against HCT116 cells with IC50 = 1.8-80.4 μM. Compounds 9p, 9r, and 9s demonstrated competitive antiproliferative activities to sorafenib, against all two cancer cell lines. The structures of all the newly synthesized compounds were determined by 1H NMR, 13C NMR, and HRMS, and compound 9n was characterized by single-crystal X-ray diffraction. Primary structure-activity relationships (SAR) have also been established.

Synthesis and biological evaluation of novel N-methyl-picolinamide-4-thiol derivatives as potential antitumor agents

A novel series of N-methylpicolinamide-4-thiol derivatives were synthesized and evaluated on human cancer cell lines. Among them, compound 6p displayed potent and broad-spectrum anti-proliferative activities in vitro on some human cancer cell lines, even better than sorafenib. The advanced kinase inhibitory assays showed that compound 6p could selectively inhibit Aurora-B kinase. The biological results were rationalized by the molecular docking study, which indicated the stable interactions of 6p with the Aurora-B kinase.