28447-26-9Relevant articles and documents
Michaelis-Arbuzov-type reaction of 1-imidoalkyltriarylphosphonium salts with selected phosphorus nucleophiles
Adamek, Jakub,egrzyk-Schlieter, Anna W.,Ste?, Klaudia,Walczak, Krzysztof,Erfurt, Karol
, (2019/09/30)
In this study, Michaelis-Arbuzov-type reaction of 1-imidoalkyltriarylphosphonium salts with phosphites, phosphonites, and phosphinites was used in the synthesis of a wide range of phosphorus analogs of α-amino acids such as 1-imidoalkylphosphonates, 1-imidoalkylphosphinates, and 1-imidoalkylphosphine oxides. Large differences were observed in the reactivity of substrates depending on their structure, especially on the type of phosphonium moiety and N-protecting group. The conditions under which the expected products can be obtained in good to excellent yields have been developed. Mechanistic aspects of the transformation have been provided.
Inhibitors of β-lactamase
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, (2008/06/13)
The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural p
Novel Inhibitors of beta-lactamase
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, (2008/06/13)
The invention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural p