28456-53-3

Basic information

• Product Name: 4(1H)-Pyrimidinone,2,3-dihydro-6-(1-methylethyl)-2-thioxo-
• Synonyms: 4(1H)-Pyrimidinone,2,3-dihydro-6-(1-methylethyl)-2-thioxo-
• CAS NO: 28456-53-3
• Molecular Formula: C₇H₁₀N₂OS
• Molecular Weight: 170.2321
• Mol File: 28456-53-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 344.1°Cat760mmHg
• Flash Point: 161.9°C
• Appearance: /
• Density: 1.23g/cm³
• Vapor Pressure: 3.39E-05mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: 4(1H)-Pyrimidinone,2,3-dihydro-6-(1-methylethyl)-2-thioxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Pyrimidinone,2,3-dihydro-6-(1-methylethyl)-2-thioxo-(28456-53-3)
• EPA Substance Registry System: 4(1H)-Pyrimidinone,2,3-dihydro-6-(1-methylethyl)-2-thioxo-(28456-53-3)

Safety Data

• Hazardous Substances Data: 28456-53-3(Hazardous Substances Data)

Usage

General Description

4(1H)-Pyrimidinone,2,3-dihydro-6-(1-methylethyl)-2-thioxo- is a chemical compound with the molecular formula C9H12N2OS. It is a heterocyclic compound that contains a pyrimidine ring with a thioxo group and an isopropyl substituent. 4(1H)-Pyrimidinone,2,3-dihydro-6-(1-methylethyl)-2-thioxo- has potential applications in pharmaceutical and agricultural industries due to its structural features and potential biological activities. It is important to handle and use this chemical with caution, following proper safety protocols and guidelines to prevent any potential hazards or risks associated with its handling and use. Additionally, further research and studies are needed to fully understand the properties and potential applications of this compound.

InChI:InChI=1/C7H10N2OS/c1-4(2)5-3-6(10)9-7(11)8-5/h3-4H,1-2H3,(H2,8,9,10,11)

Upstream product

• 17356-08-0 thiourea 
• 7152-15-0 ethyl 4-methyl-3-oxo-pentanoate 
• 563-80-4 3-methyl-butan-2-one 
• 42558-54-3 Methyl 4-methyl-3-oxopentanoate 

Downstream Products

• 58289-27-3 6-isopropyl uracil 
• 58289-27-3 2,4-dihydroxy-6-isopropylpyrimidine 
• 58289-29-5 2,4-dichloro-5-nitro-6-isopropylpyrimidine 
• 58289-28-4 6-isopropyl-2,4-dihydroxy-5-nitropyrimidine 

Relevant articles and documents

Laccase-catalyzed green synthesis and cytotoxic activity of novel pyrimidobenzothiazoles and catechol thioethers

The laccase-catalyzed reaction between unsubstituted catechol and 2-thioxopyrimidin-4(1H)-ones using aerial O2 as the oxidant delivers novel pyrimidobenzothiazoles with high yields in an aqueous solvent system under mild reaction conditions. With 4-substituted catechols, catechol thioethers are formed exclusively. The synthetic protocols developed provide a sustainable approach for these compound classes. In addition, the cytotoxicity of the products against HepG2 cell line is reported. Most compounds exhibit antiproliferative activities with IC50 values at the micromolar level. A structure-activity relationship study will facilitate the further development of these compounds as cytotoxic agents.

Structure-Activity Relations. Part 12. Antibacterial Activity of a Series of 2,4-Diamino-6-substituted 5-(4-pyridylmethylamino)pyrimidines and 2,4-Diamino-5-(4-substituted benzylamino)pyrimidines.

A series of 6-substituted 2,4-diamino-5-(4-pyridylamino)pyrimidines and of 2,4-diamino-5-(4-substituted benzylamino)pyrimidines has been prepared.Their antibacterial activity towards L. casei, S. aureus and E. coli has been investigated.These activities have been successfully correlated by Hansch-type relations.Dependence on both lipophilicity and electronic (polar) factors has been found.The results are related to the structure and interactions with the receptor.