28458-45-9

Basic information

• Product Name: N-tert-Butyl-2-nitroaniline
• Synonyms: N-tert-Butyl-2-nitroaniline
• CAS NO: 28458-45-9
• Molecular Formula: C₁₀H₁₄N₂O₂
• Molecular Weight: 194.23036
• Mol File: 28458-45-9.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-tert-Butyl-2-nitroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-Butyl-2-nitroaniline(28458-45-9)
• EPA Substance Registry System: N-tert-Butyl-2-nitroaniline(28458-45-9)

Safety Data

• Hazardous Substances Data: 28458-45-9(Hazardous Substances Data)

Usage

Description

N-tert-Butyl-2-nitroaniline is an organic compound with the molecular formula C10H14N2O2. It is a derivative of aniline, featuring a tert-butyl group and a nitro group attached to the benzene ring. N-tert-Butyl-2-nitroaniline is known for its chemical reactivity and is often utilized in the synthesis of various pharmaceutical compounds.

Uses

Used in Pharmaceutical Industry:
N-tert-Butyl-2-nitroaniline is used as a reactant for the preparation of benzimidazol-2-ones. These benzimidazol-2-ones are potent, selective, and orally efficacious norepinephrine reuptake inhibitors. They play a crucial role in the development of medications targeting conditions such as attention deficit hyperactivity disorder (ADHD) and depression, where the regulation of norepinephrine levels in the brain is essential for symptom management.

Upstream product

• 88-73-3 2-Chloronitrobenzene 
• 75-64-9 tert-butylamine 
• 1493-27-2 ortho-nitrofluorobenzene 
• 88-74-4 2-nitro-aniline 
• 115-11-7 isobutene 

Downstream Products

• 28458-68-6 N¹-(tert-butyl)benzene-1,2-diamine 
• 180207-92-5 3-Phenyl-4,5-dihydro-imidazo[1,5-a]quinoxaline 
• 180207-91-4 3-p-Tolyl-4,5-dihydro-imidazo[1,5-a]quinoxaline 
• 531509-85-0 3-phenylimidazo[1,5-a]quionxalin-4(5H)-one 
• 148858-16-6 3-(4-fluorophenyl)-4,5-dihydroimidazo[1,5-a]quinoxaline 
• 180207-90-3 3-p-Tolyl-5H-imidazo[1,5-a]quinoxalin-4-one 
• 180207-88-9 3-(4-Methoxy-phenyl)-4,5-dihydro-imidazo[1,5-a]quinoxaline 
• 180207-87-8 5-tert-Butyl-3-(4-fluoro-phenyl)-4,5-dihydro-imidazo[1,5-a]quinoxaline 
• 1026530-67-5 3-Phenyl-4H-imidazo[1,5-a]quinoxaline-5-carbonyl chloride 
• 180207-89-0 5-tert-Butyl-3-p-tolyl-5H-imidazo[1,5-a]quinoxalin-4-one 
• 148858-14-4 5-tert-butyl-3-(4-fluorophenyl)-4,5-dihydroimidazo[1,5-a]quinoxalin-4-one 
• 1025964-23-1 5-tert-Butyl-3-(4-methoxy-phenyl)-5H-imidazo[1,5-a]quinoxalin-4-one 
• 1026714-68-0 3-(4-Fluoro-phenyl)-4H-imidazo[1,5-a]quinoxaline-5-carbonyl chloride 

Relevant articles and documents

Molecular Scissors for Tailor-Made Modification of Siloxane Scaffolds

The controlled design of functional oligosiloxanes is an important topic in current research. A consecutive Si?O?Si bond cleavage/formation using siloxanes that are substituted with 1,2-diaminobenzene derivatives acting as molecular scissors is presented.

CRBN LIGANDS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.

GSK-3BETA INHIBITOR

For the purpose of providing a GSK-3β inhibitor containing a 2-aminopyridine compound or a salt thereof or a prodrug thereof useful as an agent for the prophylaxis or treatment of a GSK-3β-related pathology or disease, the present invention provides a GSK-3β inhibitor containing a compound represented by the formula (IA): wherein each symbol is as defined in the specification. or a salt thereof or a prodrug thereof.