28459-40-7 Usage
Description
10-Formyldihydrofolate, also known as 10-Formyl-7,8-dihydrofolic acid, is a unique folate derivative that has been identified in methotrexate-treated cells. It is not typically found as a component of intracellular folates in normal tissues but has been discovered in the cytosol of methotrexate (MTX)-treated MCF-7 breast cancer cells and normal human myeloid precursor cells. This distinctive characteristic makes 10-formyldihydrofolate a potential target for cancer therapies and other applications.
Uses
Used in Cancer Research and Treatment:
10-Formyldihydrofolate is used as a target for cancer therapies, particularly in methotrexate-treated cells. Its presence in the cytosol of certain cancer cells and normal human myeloid precursor cells suggests that it may play a role in the development and progression of cancer. By targeting 10-formyldihydrofolate, researchers can potentially develop new treatments that specifically affect cancer cells while sparing healthy cells.
Used in Drug Development:
10-Formyldihydrofolate is used as a target for the development of novel drugs that can exploit its unique presence in methotrexate-treated cells. By designing drugs that interact with 10-formyldihydrofolate, researchers can potentially create therapies that are more effective and selective in treating cancer.
Used in Diagnostics:
10-Formyldihydrofolate can be used as a biomarker for the detection and monitoring of methotrexate-treated cancers. Its presence in the cytosol of certain cancer cells and normal human myeloid precursor cells can serve as an indicator of the effectiveness of methotrexate treatment and the potential for cancer recurrence.
Used in Understanding Folate Metabolism:
10-Formyldihydrofolate is used as a research tool to better understand the role of folate metabolism in cancer cells and normal cells. By studying the mechanisms and pathways involving 10-formyldihydrofolate, researchers can gain insights into the complex interplay between folate metabolism and cellular processes, potentially leading to the development of new therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 28459-40-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,4,5 and 9 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 28459-40:
(7*2)+(6*8)+(5*4)+(4*5)+(3*9)+(2*4)+(1*0)=137
137 % 10 = 7
So 28459-40-7 is a valid CAS Registry Number.
InChI:InChI=1/C20H21N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,13H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/t13-/m0/s1
