28467-42-7

Basic information

• Product Name: trans-4-t-butylcyclohexanecarbonyl chloride
• Synonyms: trans-4-t-butylcyclohexanecarbonyl chloride
• CAS NO: 28467-42-7
• Molecular Weight: 202.724
• Mol File: 28467-42-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: trans-4-t-butylcyclohexanecarbonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: trans-4-t-butylcyclohexanecarbonyl chloride(28467-42-7)
• EPA Substance Registry System: trans-4-t-butylcyclohexanecarbonyl chloride(28467-42-7)

Safety Data

• Hazardous Substances Data: 28467-42-7(Hazardous Substances Data)

Upstream product

• 943-29-3 trans-4-(tert-butyl)cyclohexane-1-carboxylic acid 
• 98-52-2 4-(1,1-dimethylethyl)-cyclohexanol 
• 28467-41-6 cis-4-tert-butylcyclohexanecarboxylic acid chloride 

Downstream Products

• 907-04-0 bis-(trans-4-tert-butyl-cyclohexanecarbonyl)-peroxide 
• 28125-13-5 1-(4-tert-Butyl-cyclohexyl)-2-diazo-ethanone 
• 1514926-87-4 (trans)-4-(tert-butyl)-N-(quinolin-8-yl)cyclohexane-1-carboxamide 
• 28125-17-9 methyl trans-(4-t-butylcyclohexyl)acetate 
• 28125-18-0 trans-4-tert-butylcyclohexylacetic acid 
• 28125-22-6 1-(4-tert-Butyl-cyclohexyl)-propan-2-ol 
• 28125-19-1 1-(4-tert-Butyl-cyclohexyl)-propan-2-one 
• 28112-58-5 trans-4-tert-Butylcyclohexylphenylmethanol 
• 28112-56-3 trans-(4-tert-Butylcyclohexyl)phenylketon 

Relevant articles and documents

Palladium-Catalyzed Migratory Insertion of Carbenes and C-C Cleavage of Cycloalkanecarboxamides

A palladium catalyzed reaction of cycloalkanecarboxamides and diazomalonates or bis(phenylsulfonyl)diazomethane has been developed. The reaction proceeds via carbene migratory insertion and cascade C-C cleavage pathways. Cycloalkanecarboxamides with four to seven membered rings are applicable in the transformation. A series of ring opening products were prepared with moderate yields. The finding provides valuable clues for the development of new reactions involving carbene migratory insertion and the cleavage of unstrained C(sp3)-C(sp3) bonds.

Containing halogenated phenyl trans-cyclohexane amide compound and use thereof

The invention relates to the field of thrombotic disease related medicines. Specifically, the invention relates to a trans-cyclohexane amide structured PAR-1 antagonist containing structures, such as halogenated phenyl and the like, a preparation method of the antagonist and application of the antagonist in preparation of medicines for treating thrombotic diseases, wherein R is selected from C1-C3 alkyl, C3-C5 cycloalkyl and halogen substituent.

Alkoxy phenyl-substituted trans-cyclohexane amide compound and use thereof

The invention relates to the field of thrombotic disease related medicines. Specifically, the invention relates to a terminal alkoxy phenyl substituted trans-cyclohexane amide structured PAR-1 antagonist, a preparation method thereof and application of the antagonist in preparation of medicines for treating thrombotic diseases, wherein R is selected from C1-C3 alkyl and C3-C5 cycloalkyl.