2850-96-6Relevant articles and documents
Practical amination of nitropyridones by silylation
Singer, Robert A.,Dore, Michael
, p. 1261 - 1264 (2008)
A practical method for coupling nitropyridones (1) with primary amines by treatment with hexamethyldisilazane has been developed, avoiding the use of hazardous reagents such as POCl3. The activation of the pyridone by a nitro group is necessary for efficient coupling, leading to aminonitropyridines (3) in good yields. Regioisomers other than 3-nitro-4-pyridone (1) were found to be substantially less reactive but would undergo coupling with primary amines.