28539-02-8 Usage
Description
1H-Benzotriazole-1-methanol is an organic compound with the molecular formula C7H7N3O and is characterized by its heterocyclic structure containing a benzene ring fused to a triazole ring. It is a versatile molecule with various applications across different industries due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
1H-Benzotriazole-1-methanol is used as a catalyst for the hydrolysis of phenyl esters of α-furoic acid, which is an important step in the synthesis of various pharmaceutical compounds.
Used in Chemical Industry:
1. 1H-Benzotriazole-1-methanol is used as a corrosion inhibitor of iron in aerated acidic media, protecting metal surfaces from degradation and extending their lifespan.
2. It serves as a reactive oxygen scavenger, neutralizing reactive oxygen species that can cause damage to materials and structures.
Used in Synthesis:
1. 1H-Benzotriazole-1-methanol is used as a reactant for the synthesis of hydroxy-skipped bis-homo-inositol derivatives, which have potential applications as glycosidase inhibitors.
2. It is utilized in the enantioselective synthesis of aplysin, a natural product with potential pharmaceutical applications, through a palladium-catalyzed addition of an arylboronic acid to an allenic alcohol, followed by Eschenmoser/Claisen rearrangement.
3. 1H-Benzotriazole-1-methanol is also used in the synthesis of substituted dihydroquinoline carboxylic acids, which have been identified as potential antitumor and HIV-1 integrase inhibitors.
4. Additionally, 1H-Benzotriazole-1-methanol is employed in the Gosteli-Claisen rearrangement, a chemical reaction that involves the rearrangement of allyl vinyl ethers to γ,δ-unsaturated alcohols, which are valuable synthetic intermediates in the preparation of various organic compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 28539-02-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,5,3 and 9 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 28539-02:
(7*2)+(6*8)+(5*5)+(4*3)+(3*9)+(2*0)+(1*2)=128
128 % 10 = 8
So 28539-02-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H7N3O/c11-5-10-7-4-2-1-3-6(7)8-9-10/h1-4,11H,5H2
28539-02-8Relevant articles and documents
N-Hydroxymethylation of 3-Aryl-2-cyanoprop-2-enethioamides
Chigorina, E. A.,Dotsenko, V. V.,Krivokolysko, S. G.
, p. 1411 - 1417 (2020/09/21)
Abstract: Hydroxymethylation of (E)-3-aryl-2-cyanoprop-2-enethioamides with an aqueous alcoholic solution of formaldehyde has afforded (E)-3-aryl-N-(hydroxymethyl)-2-cyanoprop-2-enethioamides. The predictive analysis of the biological activity of the obtained compounds in silico has been carried out.
