2858-20-0

Basic information

• Product Name: 4-AMINO-5-CHLORO-2,6-DIMETHYLPYRIMIDINE
• Synonyms: TIMTEC-BB SBB004000;LABOTEST-BB LT00012591;4-AMINO-5-CHLORO-2,6-DIMETHYLPYRIMIDINE;4-AMINO-2-CHLORO-6,7-DIMETHYLPYRIMIDINE
• CAS NO: 2858-20-0
• Molecular Formula: C₆H₈ClN₃
• Molecular Weight: 157.6
• Product Categories: Pyridines, Pyrimidines, Purines and Pteredines;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrimidines;PyrimidinesHeterocyclic Building Blocks;Building Blocks;C6 to C8;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks
• Mol File: 2858-20-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 164-166 °C(lit.)
• Boiling Point: 257.1 °C at 760 mmHg
• Flash Point: 109.3 °C
• Appearance: /
• Density: 1.284 g/cm³
• Vapor Pressure: 0.0149mmHg at 25°C
• Refractive Index: 1.586
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 5.49±0.10(Predicted)
• CAS DataBase Reference: 4-AMINO-5-CHLORO-2,6-DIMETHYLPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-5-CHLORO-2,6-DIMETHYLPYRIMIDINE(2858-20-0)
• EPA Substance Registry System: 4-AMINO-5-CHLORO-2,6-DIMETHYLPYRIMIDINE(2858-20-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 2858-20-0(Hazardous Substances Data)

Usage

Description

4-Amino-5-chloro-2,6-dimethylpyrimidine (ACDP) is an aminopyrimidine derivative known for its potential applications in various fields due to its unique chemical properties. It is characterized by its interaction as an electron donor with a σ-electron acceptor, such as iodine.

Uses

Used in Chemical Research:
4-AMINO-5-CHLORO-2,6-DIMETHYLPYRIMIDINE is used as a nucleobase standard for systematic quantitative structure-retention relationship (QSRR) studies on pyrimidines. This application is crucial for understanding the relationship between molecular descriptors (variables) and their chromatographic retention (experimental unit), which can be vital in the development of new drugs and chemical compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-AMINO-5-CHLORO-2,6-DIMETHYLPYRIMIDINE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a versatile building block for the development of new drugs with potential applications in treating different diseases.
Used in Analytical Chemistry:
4-AMINO-5-CHLORO-2,6-DIMETHYLPYRIMIDINE is employed as a reference compound in analytical chemistry, particularly in chromatographic techniques. Its use as a standard helps in the accurate determination of retention times and the identification of other related compounds in complex mixtures.
Used in Material Science:
The unique electronic properties of 4-AMINO-5-CHLORO-2,6-DIMETHYLPYRIMIDINE make it a potential candidate for use in the development of new materials with specific electronic or optical properties. Its interaction with electron acceptors like iodine can be exploited to design materials with tailored characteristics for various applications.

InChI:InChI=1/C6H8ClN3/c1-3-5(7)6(8)10-4(2)9-3/h1-2H3,(H2,8,9,10)

Upstream product

• 121-60-8 p-acetylaminobenzenesulfonyl chloride 

Downstream Products

• 119271-21-5 C₁₄H₁₅ClN₄O₃S 
• 119271-16-8 C₁₃H₁₂Cl₂N₄O₃S 
• 119271-18-0 C₁₄H₁₅ClN₄O₃S 
• 119271-20-4 N-phenylsulfonyl-N'-(5-chloro-2,6-dimethylpyrimidin-4-yl)urea 
• 54951-54-1 N-[4-(dimethylamino-4-ylsulfonyl)phenyl]acetamide 
• 63-74-1 sulfanilamide 
• 4015-18-3 Sulfaclomid 
• 84729-42-0 C₂₂H₂₂ClN₅O₆S₂ 
• 4049-04-1 4-(4'-Acetylaminobenzensulfonyl)amino-5-chlor-2,6-dimethylpyrimidin 
• 119304-10-8 C₁₃H₁₂ClN₄O₃S^(1-)*Na⁽¹⁺⁾ 
• 1246225-52-4 5-chloro-2,6-dimethyl-N-(2-vinylphenyl)pyrimidin-4-amine 

Relevant articles and documents

Studies of the synthesis of sulfonamides: An improved preparation of Sulfaclomid

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