285986-31-4

Basic information

• Product Name: STAT5 Inhibitor
• Synonyms: STAT5 Inhibitor;STAT5-IN-1;N'-[(4-oxo-4H-chromen-3-yl)methylene]nicotinohydrazide;STAT5 Inhibitor 1;(E)-N'-((4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide;MDK6314
• CAS NO: 285986-31-4
• Molecular Formula: C16H11N3O3
• Molecular Weight: 293.27684
• EINECS: -0
• Mol File: 285986-31-4.mol
• Article Data: 0

Chemical Properties

• Melting Point: 214-216 °C
• Appearance: /
• Density: 1.33±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• Solubility: ≥9.58 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
• PKA: 10.44±0.46(Predicted)
• CAS DataBase Reference: STAT5 Inhibitor(CAS DataBase Reference)
• NIST Chemistry Reference: STAT5 Inhibitor(285986-31-4)
• EPA Substance Registry System: STAT5 Inhibitor(285986-31-4)

Safety Data

• Hazardous Substances Data: 285986-31-4(Hazardous Substances Data)

Usage

Description

N-[(4-oxochromen-3-yl)methylideneamino]pyridine-3-carboxamide, also known as a STAT5 Inhibitor, is a carbohydrazide derived from nicotinohydrazide. It is characterized by the formal condensation of the terminal nitrogen with the aldehyde group of 4-oxo-4H-chromene-3-carbaldehyde. N-[(4-oxochromen-3-yl)methylideneamino]pyridine-3-carboxamide is a potent inhibitor of the STAT5 protein, which plays a crucial role in the regulation of gene expression in response to various extracellular signaling molecules.

Uses

Used in Pharmaceutical Industry:
N-[(4-oxochromen-3-yl)methylideneamino]pyridine-3-carboxamide is used as a selective inhibitor of STAT5 for targeting overactive STAT5 in several types of leukemias and various solid tumors. Its application is based on its ability to suppress STAT5 by targeting its SH2 domain, thereby blocking STAT5/STAT5 DNA binding in cancer cells and potentially inhibiting tumor growth and progression.
Used in Cancer Research:
In the field of cancer research, N-[(4-oxochromen-3-yl)methylideneamino]pyridine-3-carboxamide serves as a valuable tool for studying the role of STAT5 in cancer development and progression. Its selective inhibition of STAT5 can help researchers understand the molecular mechanisms underlying the overactivity of this protein in various cancers and identify potential therapeutic targets for the development of novel anticancer drugs.
Used in Drug Development:
N-[(4-oxochromen-3-yl)methylideneamino]pyridine-3-carboxamide is used as a lead compound in the development of new drugs targeting STAT5-mediated signaling pathways. Its selective inhibition of STAT5 makes it a promising candidate for the design and synthesis of more potent and specific STAT5 inhibitors, which could be used in combination with conventional chemotherapeutic drugs to enhance their efficacy and overcome drug resistance in cancer treatment.

references

[1]. müller j, sperl b, reindl w, et al. discovery of chromone-based inhibitors of the transcription factor stat5. chembiochem. 2008 mar 25;9(5):723-7.[2]. leonard wj, o'shea jj. jaks and stats: biological implications. annu rev immunol. 1998;16:293-322.[3]. schindler c, darnell je jr. transcriptional responses to polypeptide ligands: the jak-stat pathway. annu rev biochem. 1995;64:621-51.