28610-34-6Relevant articles and documents
Dimethylallyl diphosphate: Kaempferol 8-dimethylallyl transferase in Epimedium diphyllum cell suspension cultures
Yamamoto, Hirobumi,Kimata, Junko,Senda, Masayuki,Inoue, Kenichiro
, p. 23 - 28 (1997)
The enzymatic formation of des-O-methylanhydroicaritin from dimethylallyl diphosphate and kaempferol was investigated in the cell-free extract of Epimedium diphyllum cell suspension cultures. The enzyme catalysing the dimethylallyl group transfer to C-8 position of kaempferol (EC 2.5.1.) was membrane-bound and required divalent cations such as Mg2+ and Mn2+. Mg2+ was the most effective for the reaction. The enzyme showed a very broad pH optimum in the alkaline region, pH 7.5-11.0. It required dimethylallyl diphosphate as a sole prenyl donor, but had a rather broad substrate specificity for the prenyl acceptor. Not only kaempferol, but also quercetin (39%), apigenin (60%) and luteolin (34%) were prenylated, whereas kaempferol glycosides, naringenin and genistein were not prenylated. These results suggested that the prenylation reaction of kaempferol precedes the glycosylation step in epimedoside A biosynthesis. The apparent K(m) values for dimethylallyl diphosphate and kaempferol were 0.58 and 0.13 mM, respectively.
The first total synthesis of sophoflavescenol, flavenochromane C, and citrusinol
Nguyen, Van-Son,Dong, Lin-Pei,Wang, Sheng-Chun,Wang, Qiuan
, p. 2297 - 2302 (2015/04/14)
The first total syntheses of sophoflavescenol (1), flavenochromane C (2), and citrusinol (3) were achieved. These three naturally occurring prenylated or prenyl-cyclized flavonoids have important biological activities such as cytotoxicity against some can
A 2,2-DIMETHYLPYRANOFLAVONOL FROM CITRUS NOBILIS
Wu, Tian-Shung
, p. 3094 - 3095 (2007/10/02)
An investigation of the root bark constituents of Citrus nobilis var. sunki has afforded a sesquiterpene , six coumarins , and four acridone alkaloids together with p-hidroquinone.A new 2,2-dimethylpyranoflavonol was also isolated, identified and named citrusinol. Key Word Index - Citrus nobilis var. sunki; Rutaceae; citrusinol; flavonoids; coumarins; sesquiterpene; acridone alkaloids; homoacridone alkaloids.