28614-96-2

Basic information

• Product Name: N-(benzylcarbamoyl)acetamide
• Synonyms: N-(benzylcarbamoyl)acetamide
• CAS NO: 28614-96-2
• Molecular Weight: 192.217
• Mol File: 28614-96-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(benzylcarbamoyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(benzylcarbamoyl)acetamide(28614-96-2)
• EPA Substance Registry System: N-(benzylcarbamoyl)acetamide(28614-96-2)

Safety Data

• Hazardous Substances Data: 28614-96-2(Hazardous Substances Data)

Upstream product

• 103-81-1 Benzeneacetamide 
• 79-15-2 N-bromoacetamide 
• 538-32-9 benzylurea 
• 108-24-7 acetic anhydride 
• 3998-25-2 acetyl isocyanate 
• 100-46-9 benzylamine 
• 127-09-3 sodium acetate 

Relevant articles and documents

Hofmann Rearrangement of Carboxamides Mediated by N-Bromoacetamide

An efficient, one-pot procedure for the Hofmann rearrangement of aromatic and aliphatic amides has been developed. Methyl and benzyl carbamates are produced with N-bromoacetamide in the presence of lithium hydroxide or lithium methoxide, in high yields. β-Phenylamino amides gave five-membered cyclic ureas stereospecifically. Side products of aryl or benzyl bromination were minimized. This procedure offers an easy access to various protected amines or diamines, which represent important synthetic precursors.

Solid-phase synthesis of disubstituted N -acylureas from resin-bound ureas and acyl chlorides

Acylureas (ureides) are valued for their important biological activities. Whereas cyclic acylureas have frequently been the object of solid-phase chemistry, only few reports have focused on the solid-supported preparation of acyclic representatives. We have prepared different types of acylureas on Rink amide resin in three or four steps. The products are either N-acylated (9, 18), N-acylated-N′-alkylated (10, 19), or N-acylated-N-alkylated (22). Characteristic NMR parameters of isomeric acylureas 10, 19, and 22 are discussed.

CONDENSATION OF ACYL CHLORIDE ON SODIUM CYANATE : PREPARATION OF ACYL ISOCYANATES

The catalytic effects of various metal halides and solvents on the reaction of benzoyl chloride with sodium cyanate were studied.It has been found that SnCl4, and ZnCl2 catalyze the reaction to give the corresponding acyl isocyanates in good yields.The scope of the reaction was studied and a number of aroyl isocyanates and their derivatives were prepared.A few non aromatic isocyanates and their derivatives were also prepared.