2863-04-9

Basic information

• Product Name: thymidine 3',5'-diphosphate
• Synonyms: thymidine 3',5'-diphosphate
• CAS NO: 2863-04-9
• Molecular Formula: C₁₀H₁₆N₂O₁₁P₂
• Molecular Weight: 402.188362
• Mol File: 2863-04-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.83g/cm³
• PKA: 1.83±0.10(Predicted)
• CAS DataBase Reference: thymidine 3',5'-diphosphate(CAS DataBase Reference)
• NIST Chemistry Reference: thymidine 3',5'-diphosphate(2863-04-9)
• EPA Substance Registry System: thymidine 3',5'-diphosphate(2863-04-9)

Safety Data

• Hazardous Substances Data: 2863-04-9(Hazardous Substances Data)

Upstream product

• 538-37-4 dibenzyl phosphochloridate 
• 50-89-5 thymidine 

Relevant articles and documents

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A 13Cmr study of 2'-deoxynucleotides in the syn and anti conformation

The geminal and vicinal 13C-31P coupling constants for the 3'- and 5'-monophosphates and 3',5'-diphosphates of thymidine and its isomer 6-methyl-2'-deoxyuridine have been obtained for aqueous solutions at various pH values.Since the thymine base is anti and the 6-methyluracil base is syn, the data provide information about the influence of the orientation about the N-glycosyl linkage on the conformation about the C(5')-O(5')(φ) and C(3')-O(3')(φ') bonds.The 3J(C4'-P5') couplings reveal a preference for the t(φ) conformer of the 5'-nucleotidyl units, in agreement with previous measurements of 1H-31P coupling constants.The 3J(C4'- P3') and 3J(C2'-P3') couplings are consistent with a preference for the t(φ') conformer for both the syn and anti 3'-nucleotidyl units.The response of these couplings to secondary ionization of the phosphate is different for the thymine and 5-methyluracil derivatives and suggests a phosphate-phosphate interaction for the syn, but not the anti, 3',5'-diphosphates.A correlation between the sugar-pucker and the φ' orientation is revealed.The 2J(C5'-P5') and 2J(C3'-P3') are relatively insensitive to the ionization state of the phosphate as well as to other structural features of the deoxyribose phosphate backbone.