28643-80-3 Usage
Description
Nigericin sodium salt, also known as Nigericin Na, is a polyether ionophore derived from the atypical polyether antibiotic, nigericin. It is characterized by its high affinity for monovalent cations such as Na+ and K+, and its ability to disrupt membrane potential and stimulate ATPase activity in mitochondria. Nigericin sodium salt is a white powder and is cell permeable, with ion selectivity for K+ > Rb+ > Cs+ >> Na+.
Uses
Used in Pharmaceutical Industry:
Nigericin sodium salt is used as an ionophore for its ability to transport monovalent cations across membranes, which has potential applications in the development of drugs targeting ion transport mechanisms.
Used in Research and Development:
Nigericin sodium salt is used as a research tool for studying the consequences of changes in membrane potential in various systems, as it disrupts membrane potential and stimulates mitochondrial ATPase activity.
Used in Antibacterial Applications:
Nigericin sodium salt is used as an antibiotic, killing bacteria by facilitating the diffusion of ions across membranes, which can be useful in the development of new antimicrobial agents.
Used in Mitochondrial Function Studies:
Nigericin sodium salt is used as a reagent to induce apoptosis resulting from intracellular acidification, making it a valuable tool for studying mitochondrial function and related cellular processes.
Biochem/physiol Actions
Product does not compete with ATP.
References
1) Akhmedov et al. (2010), Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells; FASEB J., 24 4613
2) Gong et al. (2010), Chemical probing reveals insights into the signaling mechanism of inflammasome activation; Cell Res., 20 1289
Check Digit Verification of cas no
The CAS Registry Mumber 28643-80-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,6,4 and 3 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 28643-80:
(7*2)+(6*8)+(5*6)+(4*4)+(3*3)+(2*8)+(1*0)=133
133 % 10 = 3
So 28643-80-3 is a valid CAS Registry Number.
InChI:InChI=1/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25?,26?,27-,28+,29+,30+,31+,32?,33?,34-,35?,37?,38?,39-,40+;/m0./s1
28643-80-3Relevant articles and documents
ETUDE THERMODYNAMIQUE DE LA COMPLEXATION DES IONS SODIUM, POTASSIUM ET RUBIDIUM PAR LES IONOPHORES BACTERIENS: MONENSINE, GRISORIXINE ET NIGERICINE
Pointud, Yvon,Juillard, Jean,Jeminet, Georges,David, Lucien
, p. 67 - 72 (2007/10/02)
Enthalpies in anhydrous methanol for both dissociation of carboxylic group and complexation of alkali metal cations by these natural ionophores (as 1-1 neutral association between the cation and the carboxylate form of the ionophore) are obtained from calorimetric measurements.Using equilibrium constants measured independently, it is possible to reach the corresponding entropies.The results now obtained on the thermodynamic of these two reactions are discussed in terms of "opened" or "closed" structure of the ionophores and of interactions with the solvent medium: - both acid and "empty" anion form can be considered as open in methanol; - nigericin and grisorixin have, as far as G, H, S, are concerned a very similar behaviour.The standard quantities are only shifted from grisorixin to nigericin, owing to the solvation of the supplementary OH group of the second ionophore; - monensin have a very distinct behaviour from the two other ionophores.Such thermodynamic studies are expected to give some informations on the mechanism of action of these bacterial ionophores.
