28669-35-4

Basic information

• Product Name: 3-(tert-butyl)-1-phenyl-1H-1,2,4-triazol-5(4H)-one
• Synonyms: 3-(tert-butyl)-1-phenyl-1H-1,2,4-triazol-5(4H)-one
• CAS NO: 28669-35-4
• Molecular Weight: 217.271
• Mol File: 28669-35-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-(tert-butyl)-1-phenyl-1H-1,2,4-triazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(tert-butyl)-1-phenyl-1H-1,2,4-triazol-5(4H)-one(28669-35-4)
• EPA Substance Registry System: 3-(tert-butyl)-1-phenyl-1H-1,2,4-triazol-5(4H)-one(28669-35-4)

Safety Data

• Hazardous Substances Data: 28669-35-4(Hazardous Substances Data)

Upstream product

• 100-63-0 phenylhydrazine 
• 3282-30-2 pivaloyl chloride 
• 917-61-3 sodium isocyanate 
• 41372-75-2 N-phenylhydrazone pivalyl chloride 
• 108-73-6 3,5-dihydroxyphenol 
• 42054-12-6 N’-phenyl-N-pivaloylhydrazine 

Relevant articles and documents

Synthesis of 3 H-1,2,4-Triazol-3-ones via NiCl2-Promoted Cascade Annulation of Hydrazonoyl Chlorides and Sodium Cyanate

A nickel-promoted cascade annulation reaction for the facile synthesis of 3H-1,2,4-triazol-3-ones from readily available hydrazonoyl chlorides and sodium cyanate has been developed. The transformation occurs through a cascade nickel-promoted intermolecular nucleophilic addition-elimination process, intramolecular nucleophilic addition, and a hydrogen-transfer sequence. The method has been successfully applied for the construction of the core skeleton of the angiotensin II antagonist.

Green preparation method of 1,2,4-triazol-3-one compound

The invention discloses a green preparation method of a 1,2,4-triazol-3-one compound. The green preparation method comprises the following steps: adding a nickel accelerant, triethylamine, chlorohydrazone and sodium cyanate into an organic solvent, conduc