2867-66-5Relevant articles and documents
Reactions of organozinc reagents with potassium bromodifluoroacetate
Levin, Vitalij V.,Zemtsov, Artem A.,Struchkova, Marina I.,Dilman, Alexander D.
, p. 97 - 101 (2015)
A practical method for the synthesis of gem-difluorinated compounds from organozinc reagents is described. Potassium bromodifluoroacetate serves as a source of CF2-fragment, which is inserted into carbonzinc bond of organozinc reagents. The intermediate difluorinated organozinc species can be protonated, brominated or coupled with allylic electrophiles.
Synthesis of Nitriles from Haloesters, Haloketones and Haloethers
Talekar, D. G.,Joshi, P. L.,Ramaiah, P.,Rao, A. S.
, p. 145 - 151 (2007/10/02)
The action of NaCN on haloesters, haloketones and haloethers has been studied.Haloesters wherein halogen and ester functions are located on adjacent carbon atoms, do not furnish the corresponding nitriles, whereas those with halogen and ester functions not located on adjacent carbon atoms, furnish the corresponding nitriles in good yields.The presence of hydroxy or ether function on the carbon adjacent to primary halide bearing carbon atom does not interfere in the reaction with cyanide. δ-Haloketones are transformed to ketonitriles, γ-Haloketones are transformed to cyclopropyl ketones and epoxyhalides to epoxynitriles.
On the production of new local anesthetically effective compounds
Sch?nenberger,Vogel,Bamann
, p. 371 - 378 (2007/10/05)
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