286836-12-2

Basic information

• Product Name: 1-(2-bromo-4-fluorophenoxy)propan-2-one
• Synonyms: 1-(2-bromo-4-fluorophenoxy)propan-2-one
• CAS NO: 286836-12-2
• Molecular Weight: 247.064
• Mol File: 286836-12-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(2-bromo-4-fluorophenoxy)propan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-bromo-4-fluorophenoxy)propan-2-one(286836-12-2)
• EPA Substance Registry System: 1-(2-bromo-4-fluorophenoxy)propan-2-one(286836-12-2)

Safety Data

• Hazardous Substances Data: 286836-12-2(Hazardous Substances Data)

Upstream product

• 496-69-5 2-bromo-4-fluoro-phenol 
• 78-95-5 chloroacetone 

Relevant articles and documents

Stereoselective Access to 1-[2-Bromo(het)aryloxy]propan-2-amines Using Transaminases and Lipases; Development of a Chemoenzymatic Strategy Toward a Levofloxacin Precursor

Two independent enzymatic strategies have been developed toward the synthesis of enantioenriched 1-[2-bromo(het)aryloxy]propan-2-amines. With that purpose a series of racemic amines and prochiral ketones have been synthesized from commercially available 2-bromophenols or brominated pyridine derivatives bearing different pattern substitutions in the aromatic ring. Biotransamination experiments have been studied using ketones as starting materials, yielding both the (R)- and (S)-amine enantiomers with high selectivity (91-99% ee) depending on the transaminase source. In a complementary approach, the classical kinetic resolutions of the racemic amines have been investigated using Candida antarctica lipase type B as biocatalyst. Ethyl methoxyacetate was found as a suitable acyl donor leading to the corresponding (S)-amines (90-99% ee) and (R)-amides (88-99% ee) with high selectivity in most of the cases. A preparative biotransamination process has been developed for the synthesis of (2S)-1-(6-bromo-2,3-difluorophenoxy)propan-2-amine in 61% isolated yield after 24 h, a valuable precursor of the antimicrobial agent Levofloxacin.

Aminoalkylbenzofurans as serotonin (5-HT(2c)) agonists

The present invention provides serotonergic aminoalkylbenzofurans of Formula (I): where R, R1, R2, R3, R4, R4′, R5, R5′, and R12 are as described in the specification.

BENZOFURYLPIPERAZINES AND BENZOFURYLHOMOPIPERAZINES: SEROTONIN AGONISTS

The present invention provides serotonergic benzofurylpiperazines of Formula I: where: A is a piperazine of formula: and R, R1, R2, R3, R4, R5, R5', R6, R6', R7, R7', R8, and R8' are as described in the specification.