286931-53-1

Basic information

• Product Name: 1-(3-chloro-2-hydroxy-5-methoxyphenyl)ethanone
• Synonyms: 1-(3-chloro-2-hydroxy-5-methoxyphenyl)ethanone
• CAS NO: 286931-53-1
• Molecular Weight: 200.622
• Mol File: 286931-53-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 78–79°C
• CAS DataBase Reference: 1-(3-chloro-2-hydroxy-5-methoxyphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-chloro-2-hydroxy-5-methoxyphenyl)ethanone(286931-53-1)
• EPA Substance Registry System: 1-(3-chloro-2-hydroxy-5-methoxyphenyl)ethanone(286931-53-1)

Safety Data

• Hazardous Substances Data: 286931-53-1(Hazardous Substances Data)

Usage

Preparation

Preparation by chlorination of 2-hydroxy-5-methoxyacetophenone with N-chlorosuccinimide in acetic acid containing magnesium acetate at r.t. for 24 h under nitrogen atmosphere (80%).

Upstream product

• 705-15-7 1-(2-hydroxy-5-methoxyphenyl)ethan-1-one 

Downstream Products

• 286931-55-3 methyl 3-(3-chloro-2,5-dimethoxyphenyl)-3-oxopropionate 
• 286931-54-2 3'-chloro-2',5'-dimethoxyacetophenone 

Relevant articles and documents

The synthesis of kermesic acid by acetylation-aided tautomerism of 6-chloro-2,5,8-trihydroxynaphtho-1,4-quinone

Methodology has been sought towards obtaining a 2-chloro-1,4-naphthoquinone bearing hydroxyl groups in the adjoining ring for obtaining either kermesic or carminic acids. In the first of these objectives, kermesic acid has been synthesised from 6-chloro-2,5,8-trihydroxynaphtho-1,4-quinone by the regioselective cycloaddition of the 1,2-diacetate formed by its acetylation-aided tautomerism and cycloaddition with (E)- and (Z)-3-alkoxycarbonyl-2,4-bis(trimethylsilyloxy)penta-1,3-dienes. The parent unacetylated quinone resists cycloaddition.

N-CONTAINING CHROMEN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION

The present invention provides the compounds having the general formula: (I) wherein R1 to R8, and X are as described herein, compositions including the compounds and methods of using the compounds.