286958-41-6

Basic information

• Product Name: 3-(1,3-dioxolan-2-yl)-N-cyclohexyl-2-thiophenesulfonamide
• Synonyms: 3-(1,3-dioxolan-2-yl)-N-cyclohexyl-2-thiophenesulfonamide
• CAS NO: 286958-41-6
• Molecular Weight: 317.43
• Mol File: 286958-41-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(1,3-dioxolan-2-yl)-N-cyclohexyl-2-thiophenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1,3-dioxolan-2-yl)-N-cyclohexyl-2-thiophenesulfonamide(286958-41-6)
• EPA Substance Registry System: 3-(1,3-dioxolan-2-yl)-N-cyclohexyl-2-thiophenesulfonamide(286958-41-6)

Safety Data

• Hazardous Substances Data: 286958-41-6(Hazardous Substances Data)

Upstream product

• 13250-82-3 2-(thiophen-3-yl)-1,3-dioxolane 
• 108-91-8 cyclohexylamine 
• 103011-38-7 3-(1,3-dioxolan-2-yl)thiophene-2-sulfonyl chloride 

Downstream Products

• 286958-79-0 2-cyclohexyl-3-hydroxymethyl-1,1-dioxo-1,2-dihydro-1λ⁶-thieno[3,2-e][1,2]thiazine-6-sulfonic acid amide 
• 286958-71-2 (2-cyclohexyl-1,1-dioxo-1,2-dihydro-1λ⁶-thieno[3,2-e][1,2]thiazin-3-yl)-methanol 

Relevant articles and documents

2H-Thieno[3,2-e]- and [2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxides as ocular hypotensive agents: Synthesis, carbonic anhydrase inhibition and evaluation in the rabbit

Novel non-chiral 2H-thieno[3,2-e]- and [2,3-e]-1,2-thiazine-6- sulfonamide 1,1-dioxides were synthesized for evaluation as potential candidates for the treatment of glaucoma. All of the compounds prepared were potent high affinity inhibitors of human carbonic anhydrase II, K(i) 50 values ranging from 4.25 to 73.6 nM. Of the compounds evaluated for their ability to lower intraocular pressure in naturally hypertensive Dutch-belted rabbits, 5a, 17a3, 17b1, 17b2, 17h2 and 17i1 showed significant efficacy (> 20% decrease) in this model following topical ocular administration. (C) 2000 Elsevier Science Ltd.