286958-43-8Relevant articles and documents
2H-Thieno[3,2-e]- and [2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxides as ocular hypotensive agents: Synthesis, carbonic anhydrase inhibition and evaluation in the rabbit
Chen, Hwang-Hsing,Gross, Sharon,Liao, John,McLaughlin, Marsha,Dean, Tom,Sly, William S.,May, Jesse A.
, p. 957 - 975 (2007/10/03)
Novel non-chiral 2H-thieno[3,2-e]- and [2,3-e]-1,2-thiazine-6- sulfonamide 1,1-dioxides were synthesized for evaluation as potential candidates for the treatment of glaucoma. All of the compounds prepared were potent high affinity inhibitors of human carbonic anhydrase II, K(i) 50 values ranging from 4.25 to 73.6 nM. Of the compounds evaluated for their ability to lower intraocular pressure in naturally hypertensive Dutch-belted rabbits, 5a, 17a3, 17b1, 17b2, 17h2 and 17i1 showed significant efficacy (> 20% decrease) in this model following topical ocular administration. (C) 2000 Elsevier Science Ltd.
Carbonic anhydrase inhibitors
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, (2008/06/13)
Compounds of the following formula are disclosed: Compounds of Formula I are the topic of this invention: STR1 Wherein G, J and the two atoms of the thiophene ring to which they are attached form a six-membered ring chosen from STR2 The compounds are usef