28704-27-0 Usage
Description
COP-1, also known as Copaxone, is a medication used for the treatment of relapsing-remitting multiple sclerosis. It is an amino acid polymer prepared from the N-carboxyanhydrides of Tyr, Ala, γ-benzylglutamate, and ε,N-trifluoroacetyllysine, followed by deprotection. Structurally, the random polymer simulates myelin basic protein (MBP), which gives it immunomodulating and immunosuppressive activity.
Uses
Used in Pharmaceutical Industry:
COP-1 is used as a treatment for relapsing-remitting multiple sclerosis. It exhibits immunomodulating and immunosuppressive activity, specifically targeting myelin basic protein (MBP). The mechanism of action involves binding to MHC class II (I-A/DR) molecules, which results in competition with myelin antigens for T-cell activation and induction of specific suppressor cells of the Th2 type. This antigen-specific interaction reduces the probability of long-term damage to the immune system. Copaxone has been shown to result in a 29% reduction in relapse rate and is most effective in patients with less accumulated neurologic disability.
Originator
Yeda (Israel)
Check Digit Verification of cas no
The CAS Registry Mumber 28704-27-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,7,0 and 4 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 28704-27:
(7*2)+(6*8)+(5*7)+(4*0)+(3*4)+(2*2)+(1*7)=120
120 % 10 = 0
So 28704-27-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H11NO3.C6H14N2O2.C5H9NO4.C3H7NO2/c10-8(9(12)13)5-6-1-3-7(11)4-2-6;7-4-2-1-3-5(8)6(9)10;6-3(5(9)10)1-2-4(7)8;1-2(4)3(5)6/h1-4,8,11H,5,10H2,(H,12,13);5H,1-4,7-8H2,(H,9,10);3H,1-2,6H2,(H,7,8)(H,9,10);2H,4H2,1H3,(H,5,6)/t8-;5-;3-;2-/m0000/s1
Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000
