28709-70-8

Basic information

• Product Name: N-CARBOBENZYLOXY-D-PHENYLALANINE, 99+%
• Synonyms: (S)-3-Phenyl-2-[[(benzyloxy)carbonyl]amino]propionic acid ethyl ester;N-Benzyloxycarbonyl-L-phenylalanine ethyl ester;l-n-benzyloxycarbonyl-3-phenylalanineethylester;n-benzyloxycarbonyl-3-phenyl-,ethylester,l-alanin;n-carbobenzoxy-l-phenylalanineethylester;N-CARBOBENZYLOXY-D-PHENYLALANINE, 99+%;Carbobenzyloxy-D-phenylalanine.
• CAS NO: 28709-70-8
• Molecular Formula: C₁₉H₂₁NO₄
• Molecular Weight: 299.32118
• Mol File: 28709-70-8.mol
• Article Data: 26

Chemical Properties

• Melting Point: 85-88°C
• Boiling Point: 440.65°C (rough estimate)
• Flash Point: 249.5°C
• Appearance: /
• Density: 1.1441 (rough estimate)
• Vapor Pressure: 2.76E-11mmHg at 25°C
• Refractive Index: 1.5400 (estimate)
• CAS DataBase Reference: N-CARBOBENZYLOXY-D-PHENYLALANINE, 99+%(CAS DataBase Reference)
• NIST Chemistry Reference: N-CARBOBENZYLOXY-D-PHENYLALANINE, 99+%(28709-70-8)
• EPA Substance Registry System: N-CARBOBENZYLOXY-D-PHENYLALANINE, 99+%(28709-70-8)

Safety Data

• Safety Statements: S22:Do not inhale dust.; S24/25:Avoid contact with skin and eyes.
• Hazardous Substances Data: 28709-70-8(Hazardous Substances Data)

Usage

Chemical Properties

white powder

InChI:InChI=1/C17H17NO4/c19-16(20)15(11-13-7-3-1-4-8-13)18-17(21)22-12-14-9-5-2-6-10-14/h1-10,15H,11-12H2,(H,18,21)(H,19,20)/p-1/t15-/m1/s1

Upstream product

• 64-17-5 ethanol 
• 1161-13-3 N-Cbz-L-Phe 
• 41844-49-9 2-Aethoxycarbonyloxyimino-2-cyanoacetamid 
• 3588-57-6 Z-DL-Phe-OH 
• 541-41-3 chloroformic acid ethyl ester 
• 1609-47-8 diethyl dicarbonate 
• 74-96-4 ethyl bromide 
• 3182-93-2 (L)-phenylalanine ethyl ester hydrochloride 
• 501-53-1 benzyl chloroformate 
• 3338-39-4 N-benzyloxycarbonyl-L-phenylalanyl-L-alanine 
• 55740-07-3 (4S)-4-benzyl-5-oxo-1,3-oxazolidine-3-carboxylic acid benzyl ester 
• 4816-89-1 Cbz-Phe-OCH₂CONH₂ 
• 7663-85-6 N-(carbobenzyloxy)phenylalanine cyanomethyl ester 
• 126028-14-6 2,2,2-trifluoroethyl ((benzyloxy)carbonyl)-L-phenylalaninate 

Downstream Products

• 1161-13-3 N-Cbz-L-Phe 
• 69193-13-1 Cbz-L-Phe-L-Leu-NH₂ 
• 141056-54-4 N-benzyloxycarbonyl-L-phenylalanyl-L-phenylalaninamide 
• 59830-60-3 benzyl (1S)-(1-formyl-2-phenylethyl)carbamate 
• 6372-14-1 N-((benzyloxy)carbonyl)-L-phenylalaninol 
• 26049-94-5 (S)-benzyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate 
• 90719-32-7 (S)-4-Benzyl-2-oxazolidinone 
• 100759-30-6 ethyl (S)-2-(ethylamino)-3-phenylpropanoate 
• 135219-73-7 (S)-2-{(R)-2-[3-((S)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-2-hydroxy-pentanoylamino]-4-methyl-pentanoylamino}-3-methyl-butyric acid tert-butyl ester 
• 135219-45-3 (S)-2-{(R)-2-[3-((S)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-2-oxo-pentanoylamino]-4-methyl-pentanoylamino}-3-methyl-butyric acid tert-butyl ester 
• 182742-42-3 (R)-2-[3-((S)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-2-oxo-pentanoylamino]-4-methyl-pentanoic acid tert-butyl ester 
• 72155-50-1 (3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid 
• 132549-37-2 methyl (4S,5S)-4-benzyl-2-oxooxazolidine-5-acetate 
• 132549-32-7 (S)-((4S,5S)-4-Benzyl-2-oxo-oxazolidin-5-yl)-iodo-acetic acid methyl ester 

Relevant articles and documents

Synthesis of Nitrogen-Containing Heterocycles and Cyclopentenone Derivatives via Phosphine-Catalyzed Michael Addition/Intramolecular Wittig Reaction

The phosphine-catalyzed Michael addition/intramolecular Wittig reaction between dialkyl acetylenedicarboxylate and amino-carbaldehyde or amino ester derivatives has been developped. This reaction can be rendered catalytic in phosphine by the in situ chemoselective reduction of the phosphine oxide with silane. This methodology enables rapid access to a variety of nitrogen-containing heterocycles, which are present in numerous natural products and/or bioactive compounds. Either classical heating or microwave conditions give access to the desired products in good yields (15 examples, 60–99% yields). This catalytic methodology is further applicable to the synthesis of enantioenriched 1H-pyrrole derivatives, with the use of chiral phosphines. Finally, we successfully extended the reaction to the synthesis of a polysubstituted cyclopentenone, starting from butane-2,3-dione as substrate. (Figure presented.).

COMPOUNDS USEFUL AS CSF1 MODULATORS

This invention relates to novel compounds and to pharmaceutical compositions comprising the novel compounds. More specifically, the invention relates to compounds useful as Colony Stimulating Factor 1 Receptor (cFMS) modulators (e.g. cFMS inhibitors). This invention also relates to processes for preparing the compounds, uses of the compounds in treatment and methods of treatment employing the compounds. Specifically, the invention relates to the use of the compounds for the treatment of cancer and autoimmune diseases.

Combinatorial synthesis of 3,5-Dimethylene substituted 1,2,4-Triazoles

Combinatorial cyclizations of imidates and hydrazides with methylene linked R groups, generated from the corresponding nitriles and carboxylic acids, respectively, provided a large library of 3,5-dimethylene substituted 1,2,4- trizoles. 2011 Bentham Science Publishers Ltd.