2871-28-5Relevant articles and documents
Synthesis and Hypotensive Activity of Diaboline
Kapoor, V. K.,Sharma, S. K.,Chagti, K. K.,Singh, Manjit
, p. 641 - 644 (2007/10/02)
Diaboline (4) has been prepared from strychnine through 23-isonitrosostrychnine (1) and Wieland-Gumlich aldehyde (2).It exhibits a significant hypotensive activity in anaesthetized rats and the effect is dose related.The fall in blood pressure appears to be due to the depressant effect on myocardium.