28712-62-1

Basic information

• Product Name: 5,6,7,8-tetrahydro-3-methylquinoline
• Synonyms: 5,6,7,8-tetrahydro-3-methylquinoline;3-Methyl-5,6,7,8-tetrahydro-chinolin;3-methyl-5,6,7,8-tetrahydroquinoline
• CAS NO: 28712-62-1
• Molecular Formula: C₁₀H₁₃N
• Molecular Weight: 147.21692
• EINECS: 249-183-0
• Mol File: 28712-62-1.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 250.9°Cat760mmHg
• Flash Point: 97.8°C
• Appearance: /
• Density: 1.01g/cm³
• Vapor Pressure: 0.0335mmHg at 25°C
• Refractive Index: 1.543
• PKA: 6.59±0.20(Predicted)
• CAS DataBase Reference: 5,6,7,8-tetrahydro-3-methylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6,7,8-tetrahydro-3-methylquinoline(28712-62-1)
• EPA Substance Registry System: 5,6,7,8-tetrahydro-3-methylquinoline(28712-62-1)

Safety Data

• Hazardous Substances Data: 28712-62-1(Hazardous Substances Data)

Usage

General Description

5,6,7,8-tetrahydro-3-methylquinoline is a chemical compound with the molecular formula C11H13N. It is a bicyclic aromatic compound that is commonly used in the synthesis of pharmaceuticals and organic compounds. It is a yellow liquid at room temperature, with a boiling point of approximately 249-251°C. 5,6,7,8-tetrahydro-3-methylquinoline is also known for its role as an intermediate in the production of various antimicrobial agents and as a building block for the synthesis of heterocyclic compounds. It is important in medicinal chemistry and is used in the development of novel drug molecules due to its pharmacological properties. Additionally, it is used in the perfume industry for its aromatic properties.

InChI:InChI=1/C10H13N/c1-8-6-9-4-2-3-5-10(9)11-7-8/h6-7H,2-5H2,1H3

Upstream product

• 612-58-8 3-methylquinoline 
• 2981-10-4 1-(cyclohex-1-en-1-yl)piperidine 
• 28051-68-5 methacrolein oxime 
• 71350-17-9 cyclohexanone oxime O-methallyl ether 
• 108-94-1 cyclohexanone 
• 260798-97-8 1-acetamido-2-formyl-1-cyclohexene 
• 51043-49-3 (E)-1-(N-morpholino)propene 
• 119-64-2 tetralin 
• 91-17-8 decalin 
• 14001-37-7 N-acetyl-3,4,5,6-tetrahydroaniline 
• 15295-69-9 hept-6-ynenitrile 
• 529-23-7 o-aminobenzaldehyde 
• 60247-70-3 7,8-dihydro-3-methylquinolin-5(6H)-one 

Downstream Products

• 53400-67-2 3-methyl-5,6,7,8-tetrahydroquinoline-8-thiocarboxamide 
• 53400-66-1 8-cyano-3-methyl-5,6,7,8-tetrahydroquinoline 
• 95475-95-9 (E)-5,6,7,8-tetrahydro-8-<(4-acetoxy-3-methoxyphenyl)methylene>-3-methylquinoline 
• 128581-57-7 8-benzoyl-5,6,7,8-tetrahydro-3-methylquinoline hydrochloride 
• 128581-65-7 5,6,7,8-tetrahydro-3-methyl-8-phenylthioquinoline 
• 635-46-1 1,2,3,4-tetrahydroisoquinoline 
• 95380-72-6 3,8-dimethyl-5,6,-dihydroquinoline 

Relevant articles and documents

Catalytic Co-cyclisation of α,ω-Cyanoalkynes with Alkynes: a Versatile Chemo- and Regio-selective Synthesis of 2,3-Substituted 5,6,7,8-Tetrahydroquinolines and other Cycloalkapyridines

α,ω-Cyanoalkynes are catalytically cocyclised with alkynes in the presence of dicarbonyl(cyclopentadienyl)cobalt to furnish annulated pyridines chemo- and regio-selectively.

Convenient synthesis of cobalt nanoparticles for the hydrogenation of quinolines in water

Easily accessible cobalt nanoparticles are prepared by hydrolysis of NaBH4 in the presence of inexpensive Co(ii) salts. The resulting material is an efficient catalyst for the hydrogenation of quinoline derivatives in water. The activity and chemoselectivity of this catalyst are comparable to other cobalt-based heterogeneous catalysts.

Synthesis of alkyl- and aryl-substituted pyridines from (α,β-unsaturated) imines or oximes and carbonyl compounds

Reaction of a variety of (α,β-unsaturated) imines or oximes with aliphatic aldehydes or cyclic ketones in the presence of a secondary amine afforded alkyl-, and/or aryl-, and/or cycloalkyl-substituted pyridines. To explain their formation, a hetero Diels-Alder reaction has been postulated, in which an 1-aza-1,3-butadiene reacts with an in situ generated enamine.