287121-32-8

Basic information

• Product Name: BenzeneMethanol, 5-fluoro-2-nitro-
• Synonyms: BenzeneMethanol, 5-fluoro-2-nitro-;(5-Fluoro-2-nitrophenyl)Methanol
• CAS NO: 287121-32-8
• Molecular Formula: C₇H₆FNO₃
• Molecular Weight: 171.1258432
• Mol File: 287121-32-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 286.1°C at 760 mmHg
• Flash Point: 126.8°C
• Appearance: /
• Density: 1.434g/cm³
• Vapor Pressure: 0.00126mmHg at 25°C
• Refractive Index: 1.571
• Storage Temp.: 2-8°C
• PKA: 13.50±0.10(Predicted)
• CAS DataBase Reference: BenzeneMethanol, 5-fluoro-2-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: BenzeneMethanol, 5-fluoro-2-nitro-(287121-32-8)
• EPA Substance Registry System: BenzeneMethanol, 5-fluoro-2-nitro-(287121-32-8)

Safety Data

• Hazardous Substances Data: 287121-32-8(Hazardous Substances Data)

Usage

General Description

Benzenemethanol, 5-fluoro-2-nitro-, is a chemical compound with an aromatic structure, distinguished by the presence of a benzene ring. Benzenemethanol, 5-fluoro-2-nitro- also contains an alcohol functional group - indicated by 'methanol' in the name - and nitro and fluoro substituents on the benzene ring, which contribute to its reactivity and properties. Due to its structure, it has potential usage in the manufacture of other chemicals or pharmaceuticals, and it is usually handled and stored under specific safety precautions due to its potential toxicity and reactivity. Knowledge of its detailed physical and chemical properties, such as boiling/melting points, solubility, and stability, is essential for its safe handling and use in any applications.

InChI:InChI=1/C7H6FNO3/c8-6-1-2-7(9(11)12)5(3-6)4-10/h1-3,10H,4H2

Upstream product

• 320-98-9 5-fluoro-2-nitrobenzoic acid 
• 395-81-3 5-fluoro-2-nitrobenzaldehyde 

Downstream Products

• 395-81-3 5-fluoro-2-nitrobenzaldehyde 
• 603306-52-1 5-fluoro-1H-indole-7-carbaldehyde 
• 603306-58-7 2-(dibutoxymethyl)-4-fluoro-1-nitrobenzene 
• 603300-92-1 9-fluoro-3,4-dihydro-1H-[1,4]diazepino[6,7,1-hi]indole-2-carboxylic acid tert-butyl ester 
• 603288-22-8 LY2090314 
• 82420-35-7 2-(bromomethyl)-4-fluoro-1-nitrobenzene 
• 108857-29-0 ethyl (5-fluoro-2-nitrobenzyl)aminoacetate 
• 748805-85-8 (2-amino-5-fluorophenyl)methanol 
• 109115-05-1 5-fluoro-2-nitrobenzyl chloride 
• 951667-32-6 5-[4-nitro-3-hydroxymethyl-phenoxy]-2-(toluene-4-sulfonylamino)-benzoic acid methyl ester 
• 10173-76-9 2-(5-fluoro-2-nitro-phenyl)-1H-benzoimidazole 
• 146829-56-3 2-amino-5-fluoro benzaldehyde 

Relevant articles and documents

Intramolecular Pd-catalyzed reductive amination of enolizable sp3-C-H bonds

A palladium-catalyzed reductive cyclization of nitroarenes has been designed to construct sp3-C-NHAr bonds from sp3-C-H bonds by using an enolizable nucleophile to intercept a nitrosoarene intermediate. Exposure of ortho-substituted nitroarenes to 5 mol ?% of Pd(OAc)2 and 10 mol ?% of phenanthroline under 2 atm of CO constructs partially saturated 5-, 6-, or 7-membered N-heterocycles using α-pyridyl carboxylates, malonates, 1,3-dimethylbarbituric acid, 1,3-diones, or difurans as the nucleophile.

Easy Access to Quinolin-2(1 H)-ones via a One-Pot Tandem Oxa-Michael-Aldol Sequence

An efficient strategy for the synthesis of a variety of quinolin-2(1 H)-one derivatives has been developed. The reaction proceeded from cinnamide derivatives via a tandem reaction in the presence of NaOH to afford the corresponding 2- quinolin-2(1 H)-one derivatives in good to excellent yields.

DIHYDROPYRIDINE DERIVATIVES

The present invention relates to dihydropyridine derivatives having general formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, phenyl, (1-5C)heteroaryl R2, R3 are independently (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (1-4C)alkoxy, (24C)alkenyloxy, (2-4C)alkynyloxy, halogen X is SO2, CH2, C(O) or X is absent R4 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, (3-6C)cycloalkyl, (3-6C)cycloalkenyl, (3-6C)cycloalkyl(1-4C)alkyl, (2-6C)heterocycloalkyl, (2-6C)heterocycloalkyl(14C)alkyl, (6-1 OC)aryl, (6-10C)aryl(1-4C)alkyl, (1-9C)heteroaryl or (1-9C)heteroaryl(14C)alkyl. The compounds are useful for the treatment of fertility disorders.