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287192-97-6

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287192-97-6 Usage

Physical Form

Solid

Uses

tert-Butyl 4-Ethynylpiperidine-1-carboxylate is a useful research chemical.

Check Digit Verification of cas no

The CAS Registry Mumber 287192-97-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,7,1,9 and 2 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 287192-97:
(8*2)+(7*8)+(6*7)+(5*1)+(4*9)+(3*2)+(2*9)+(1*7)=186
186 % 10 = 6
So 287192-97-6 is a valid CAS Registry Number.
InChI:InChI=1/C12H19NO2/c1-5-10-6-8-13(9-7-10)11(14)15-12(2,3)4/h1,10H,6-9H2,2-4H3

287192-97-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Ethynylpiperidine-1-carboxylic acid tert-butyl ester

1.2 Other means of identification

Product number -
Other names tert-butyl 4-ethynylpiperidine-1-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:287192-97-6 SDS

287192-97-6Downstream Products

287192-97-6Relevant articles and documents

Design and synthesis of novel triazolo-lapatinib hybrids as inhibitors of breast cancer cells

Shi, YeHui,Zhang, Wei,Li, Lixin,Tong, ZhongSheng,Bai, CuiGai

, p. 2437 - 2445 (2018)

A series of triazolo-lapatinib hybrids were synthesized via copper (II)-oxide nanoparticle (Cu2O-NP)-catalyzed azide-alkyne cycloaddition. The ability of these compounds to reduce the viability of breast cancer SKBR3 and SUM159 cells and stem cell-like KG-1a leukemia cells was subsequently evaluated. Compared with lapatinib, compounds 6c–f were more potent than lapatinib against the three cell lines. Next, the toxicity of compounds 6c–f was assessed in zebrafish. Compound 6d had comparable toxicity with lapatinib at 200 μM (mortality rate = 10 vs. 10%), and compound 6e had lower toxicity than lapatinib at 200 μM (mortality rate = 0 vs. 10%). Thus, compound 6e is a promising lead compound worthy of further investigation. [Figure not available: see fulltext.].

Novel RET inhibitors. Pharmaceutical composition and use thereof

-

, (2021/11/10)

The invention belongs to the field of medicines, and relates to a novel RET inhibitor, a pharmaceutical composition and application thereof. , The present invention relates to a compound represented by formula (I), a stereoisomer, a tautomer, an oxynitrid

SUBSTITUTED 1, 6-NAPHTHYRIDINE INHIBITORS OF CDK5

-

Page/Page column 55; 57-58, (2021/04/10)

Disclosed are compounds having structural formula I, and related salts and pharmaceutical compositions. Also disclosed are therapeutic methods, e.g., of treating diseases and conditions such as kidney disease, kidney failure, kidney stones, or polycystic kidney disease, using the compounds of formula (I), and related salts and pharmaceutical compositions.

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