287194-30-3

Basic information

• Product Name: 2-(2,5-diMethoxyphenylcarbaMoyl)phenyl acetate
• Synonyms: 2-(2,5-diMethoxyphenylcarbaMoyl)phenyl acetate;Benzamide, 2-(acetyloxy)-N-(2,5-dimethoxyphenyl)-
• CAS NO: 287194-30-3
• Molecular Formula: C₁₇H₁₇NO₅
• Molecular Weight: 315.32058
• Mol File: 287194-30-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2,5-diMethoxyphenylcarbaMoyl)phenyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,5-diMethoxyphenylcarbaMoyl)phenyl acetate(287194-30-3)
• EPA Substance Registry System: 2-(2,5-diMethoxyphenylcarbaMoyl)phenyl acetate(287194-30-3)

Safety Data

• Hazardous Substances Data: 287194-30-3(Hazardous Substances Data)

Usage

General Description

2-(2,5-dimethoxyphenylcarbamoyl)phenyl acetate is a synthetic organic compound with a chemical structure containing two benzene rings and multiple functional groups, including carbamoyl and acetate. It is often used in pharmaceutical research and drug development as a potential building block for the synthesis of novel compounds. This chemical may possess various biological activities and potential medicinal properties, making it of interest for further investigation in drug discovery and development. Additionally, its unique structure and reactivity make it a valuable tool for organic synthesis and chemical reactions in the laboratory.

Upstream product

• 102-56-7 2,5-dimethoxyaniline 
• 5538-51-2 O-acetylsalicyloyl chloride 

Downstream Products

• 287194-31-4 acetic acid 2-(6,6-dimethoxy-3-oxocyclohexa-1,4-dienylcarbamoyl)phenyl ester 
• 287194-37-0 N-(2,5-dioxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl)-2-hydroxybenzamide 
• 326499-50-7 3,3-dimethoxy-4,5-epoxy-6-hydroxy-2-salicyloylamino-cyclohexene 
• 287194-40-5 (-)-2-hydroxy-N-(2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl)benzamide 
• 287194-41-6 2-hydroxy-N-(2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl)benzamide 

Relevant articles and documents

Preparation and biological activities of optically active dehydroxymethylepoxyquinomicin, a novel NF-κB inhibitor

NF-κB is a transcription factor that induces inflammatory cytokines and anti-apoptotic proteins. We have designed a new NF-κB inhibitor based on the structure of the antibiotic epoxyquinomicin C. The designed compound, dehydroxymethylepoxyquinomicin (DHME

Synthesis of NF-κB activation inhibitors derived from epoxyquinomicin C

In order to develop new inhibitors of NF-κB activation, we designed and synthesized dehydroxymethyl derivatives of epoxyquinomicin C, namely, DHM2EQ and its regioisomer DHM3EQ. These derivatives were synthesized from 2,5-dimethoxyaniline in 5 steps. Since DHM2EQ was more active and less toxic than DHM3EQ, its stereochemical configuration was determined by X-ray crystallographic analysis. Each enantiomer of the protected DHM2EQ was separated by a chiral column and deprotected. DHM2EQ inhibited TNF-α-induced activation of NF-κB in human T cell leukemia cells, and also inhibited collagen-induced arthritis in a rheumatoid model in mice. (C) 2000 Elsevier Science Ltd. All rights reserved.